Evidence map›Paper›PMID 36451744›Full record

ArticleFrontiers in nutrition2022

Efficacy and mechanism of intermittent fasting in metabolic associated fatty liver disease based on ultraperformance liquid chromatography-tandem mass spectrometry.

Jiang Deng, Dandan Feng, Xiaoli Jia, Song Zhai, Yixin Liu, Ning Gao, Xin Zhang, Mei Li, Mengnan Lu, Chenrui Liu and 2 more

Abstract read
In one paragraph

Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jiang DengDepartment of Infectious Disease, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Dandan FengDepartment of Infectious Disease, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Xiaoli JiaDepartment of Infectious Disease, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Song ZhaiDepartment of Infectious Disease, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Yixin LiuDepartment of Infectious Disease, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Ning GaoDepartment of Infectious Disease, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Xin ZhangDepartment of Infectious Disease, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Mei LiDepartment of Infectious Disease, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Mengnan LuXi'an Jiaotong University Health Science Center, Xi'an, China.
Chenrui LiuDepartment of Infectious Disease, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Shuangsuo DangDepartment of Infectious Disease, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Juanjuan ShiDepartment of Infectious Disease, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Drug treatment of metabolic associated fatty liver disease (MAFLD) remains lacking. This study analyzes the efficacy and mechanism underlying intermittent fasting combined with lipidomics. Methods: Thirty-two male rats were randomly divided into three groups: Normal group, administered a standard diet; MAFLD group, administered a 60% high-fat diet; time-restricted feeding (TRF) group, administered a 60% high-fat diet. Eating was allowed for 6 h per day (16:00-22:00). After 15 weeks, liver lipidomics and other indicators were compared. Results: A total of 1,062 metabolites were detected. Compared with the Normal group, the weight, body fat ratio, aspartate aminotransferase, total cholesterol, low-density cholesterol, fasting blood glucose, uric acid, and levels of 317 lipids including triglycerides (TG) (17:0 Conclusion: Our results suggest that 6 h of TRF can improve MAFLD

Indexed as

intermittent fasting (IF)lipidomicsmetabolic associated fatty liver disease (MAFLD)time-restricted feeding (TRF)triglycerides

Identifiers

PMID36451744
PMCPMC9704542

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.