Evidence map›Paper›PMID 36451352›Full record

ArticleNeuroImage. Clinical2022

Spatiotemporal patterns of putaminal dopamine processing in Parkinson's disease: A multi-tracer positron emission tomography study.

Jessie Fanglu Fu, Tilman Wegener, Ivan S Klyuzhin, Julia G Mannheim, Martin J McKeown, A Jon Stoessl, Vesna Sossi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Striatal Dopamine Actions and Movement: Inferences from Parkinson Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Jessie Fanglu FuDepartment of Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA. Electronic address: flfu@mgh.harvard.edu.
Tilman WegenerDepartment of Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada; Department of Medical Engineering, University of Luebeck, Luebeck, Germany.
Ivan S KlyuzhinDivision of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Julia G MannheimDepartment of Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard-Karls University Tuebingen, Tuebingen, Germany; Cluster of Excellence iFIT (EXC 2180) "Image Guided and Functionally Instructed Tumor Therapies", University of Tuebingen, Tuebingen, Germany.
Martin J McKeownDivision of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada; Djavad Mowafaghian Centre for Brain Health, Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver, BC, Canada.
A Jon StoesslDivision of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada; Djavad Mowafaghian Centre for Brain Health, Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver, BC, Canada.
Vesna SossiDepartment of Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada; Djavad Mowafaghian Centre for Brain Health, Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver, BC, Canada.
University of British Columbia · CAVancouver Coastal Health · CASiemens (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alterations in different aspects of dopamine processing may exhibit different progressive behaviours throughout the course of Parkinson's disease. We used a novel data-driven multivariate approach to quantify and compare spatiotemporal patterns related to different aspects of dopamine processing from cross-sectional Parkinson's subjects obtained with: 1) 69 [

Indexed as

MethylphenidateParkinson DiseaseCross-Sectional StudiesDopamineDopamine Plasma Membrane Transport ProteinsHumansLevodopaPositron-Emission TomographyTomography, X-Ray ComputedDopamineDopamine Plasma Membrane Transport ProteinsLevodopaMethylphenidateMultivariate analysisParkinson’s diseasePETSpatiotemporal patternsStriatal dopamine processing

Identifiers

PMID36451352
PMCPMC9668665
OpenAlexW4307392211

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.