Evidence map›Paper›PMID 36451231›Full record

ArticleBioelectronic medicine2022

A dual tracer [

Santhoshi P Palandira, Joseph Carrion, Lauren Turecki, Aidan Falvey, Qiong Zeng, Hui Liu, Tea Tsaava, Dov Herschberg, Michael Brines, Sangeeta S Chavan and 7 more

Open access · goldAbstract read
In one paragraph

Article in Bioelectronic medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Santhoshi P Palandira *The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Joseph Carrion *The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Lauren TureckiThe Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Aidan FalveyThe Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Qiong ZengThe Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Hui LiuThe Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Tea TsaavaThe Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Dov HerschbergThe Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Michael BrinesThe Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Sangeeta S ChavanThe Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Eric H ChangThe Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
An VoThe Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Yilong MaThe Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Christine N MetzThe Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Yousef Al-AbedThe Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Kevin J TraceyThe Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Valentin A PavlovThe Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA. vpavlov@northwell.edu.ORCID http://orcid.org/0000-0002-1994-2853
Northwell Health · USFeinstein Institute for Medical Research · US

Funding

Molecular Basis of Bioelectronic MedicineR35GM118182 · NIGMS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI TRACEY, KEVIN J · 2016 to 2025
$7.3M
The ion channel TRPA1 is required for suppression of inflammation in sepsisR01GM132672 · NIGMS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI CHAVAN, SANGEETA S. · 2019 to 2025
$1.7M
NIGMS NIH HHS R01 GM132672NIGMS NIH HHS R35 GM118182
6 · The paper itself

Abstract

backgroundBrain metabolic alterations and neuroinflammation have been reported in several peripheral inflammatory conditions and present significant potential for targeting with new diagnostic approaches and treatments. However, non-invasive evaluation of these alterations remains a challenge.

methodsHere, we studied the utility of a micro positron emission tomography (microPET) dual tracer ([

resultsThere were significant increases in [

conclusionsTogether, these findings demonstrate the applicability of [

Indexed as

[11C]PBR28[18F]FDGBrainBrain metabolismConjunction analysisMicrogliaMicropet imagingMurine endotoxemiaNeuroinflammation

Identifiers

PMID36451231
PMCPMC9710165
OpenAlexW4310566814

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.