ArticleJournal of general internal medicine2023
Influence of Cost-Related Considerations on Clinical Trial Participation: Results from the 2020 Health Information National Trends Survey (HINTS).
Article in Journal of general internal medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Financial reimbursement for clinical trial participation costs: a pilot feasibility study.JNCI cancer spectrum · 2026Trial
- Understanding Cancer Clinical Trial Participation in Rural Communities: A Qualitative Focus Group Study.Psycho-oncology · 2026Article
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- Impact of community recruitment and inclusion initiatives on enrollment in the biomarker-driven MyTACTIC trial.Future oncology (London, England) · 2026Article
- Bridging the rural cancer gap: why clinical trials must include rural patients.Cancer causes & control : CCC · 2025Article
- Improving Representation of Underserved Populations in Cardiovascular Research.Journal of the American Heart Association · 2025Review
- Implementation of a Patient Navigation Program to Support Representative Participation in Cancer Clinical Trials.Cancer medicine · 2025Article
- Financial Toxicity in Cancer Clinical Trials: An Issue in Need of Clarity and Solutions.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025Article
- Financial Toxicity Among Patients With Advanced Solid Tumors Participating in Early-Phase Clinical Trials.JCO oncology practice · 2025Article
- Therapeutic Clinical Trial Eligibility and Enrollment among Women with Breast Cancer: Implications for Understanding Trial Disparities.Annals of surgical oncology · 2025Article
- Clinical trial knowledge, discussion, and participation among cancer survivors: A HINTS-SEER study.Patient education and counseling · 2025Article
- Remote Field Application of Digital Technology for Hearing Assessments in a Cohort of Pediatric Germ Cell Tumor Survivors.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Health-care organization characteristics in cancer care delivery: an integrated conceptual framework with content validation.Journal of the National Cancer Institute · 2024Article
- Understanding the financial cost of cancer clinical trial participation.Cancer medicine · 2024Article
- The influence of political ideology on clinical trial knowledge, invitation, and participation among adults in the United States.Clinical trials (London, England) · 2023Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeople experiencing financial burden are underrepresented in clinical trials.
objectiveDescribe the prevalence of cost-related considerations influential to trial participation and their associations with person-level characteristics.
designThis cross-sectional study used and assessed how three cost-related considerations would influence the decision to participate in a hypothetical clinical trial.
participantsA total of 3682 US adult respondents to the Health Information National Trends Survey MAIN MEASURES: Survey-weighted multivariable logistic regression estimated associations between respondent characteristics and odds of reporting cost-related considerations as very influential to participation. KEY
resultsAmong 3682 respondents, median age was 48 (IQR 33-61). Most were non-Hispanic White (60%), living comfortably or getting by on their income (74%), with ≥ 1 medical condition (61%). Over half (55%) of respondents reported at least one cost-related consideration as very influential to trial participation, including if usual care was not covered by insurance (reported by 42%), payment for participation (24%), or support for participation (24%). Respondents who were younger (18-34 vs. ≥ 75, adjusted odds ratio [aOR] 4.3, 95% CI 2.3-8.1), more educated (high school vs. <high school, aOR 2.1, 95% CI 1.1-4.1), or with lower perceived income (having difficulty vs. living comfortably, aOR 2.1, 95% CI 1.1-3.8) had higher odds of reporting any cost-related consideration as very influential to trial participation. Non-Hispanic Black vs. non-Hispanic White respondents had 29% lower odds (95% CI 0.5-0.9) of reporting any cost-related consideration as very influential to trial participation.
conclusionsCost-related considerations would influence many individuals' decisions to participate in a clinical trial, though prevalence of these concerns differed by respondent characteristics. Reducing financial barriers to trial participation may promote equitable trial access and greater trial enrollment diversity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.