Evidence map›Paper›PMID 36450978›Full record

ArticleNature2022

Common and rare variant associations with clonal haematopoiesis phenotypes.

Michael D Kessler, Amy Damask, Sean O'Keeffe, Nilanjana Banerjee, Dadong Li, Kyoko Watanabe, Anthony Marketta, Michael Van Meter, Stefan Semrau, Julie Horowitz and 35 more

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 205 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
205citing papers in PubMed, 5 pooled it
43.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

205 citing papers in PubMed, 5 syntheses or guidelines pooled it, 288 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Biological effects of high-LET irradiation on the circulatory system.International journal of radiation biology · 2025
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Review
  9. Article
  10. Genetic mechanisms of mitotic error in 840,853 blood genomes.medRxiv : the preprint server for health sciences · 2026
    Article
  11. Article
  12. Article
  13. Genetic influences on haematopoiesis.Nature reviews. Genetics · 2026
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Arteriosclerosis, thrombosis, and vascular biology · 2026
    Article
  19. Article
  20. Article

145 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

45 authors at 1 institution in 1 country.

Michael D KesslerRegeneron Genetics Center, Tarrytown, NY, USA.
Amy DamaskRegeneron Genetics Center, Tarrytown, NY, USA.
Sean O'KeeffeRegeneron Genetics Center, Tarrytown, NY, USA.
Nilanjana BanerjeeRegeneron Genetics Center, Tarrytown, NY, USA.
Dadong LiRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0003-0868-4884
Kyoko WatanabeRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0002-3303-8860
Anthony MarkettaRegeneron Genetics Center, Tarrytown, NY, USA.
Michael Van MeterRegeneron Pharmaceuticals, Tarrytown, NY, USA.
Stefan SemrauRegeneron Pharmaceuticals, Tarrytown, NY, USA.
Julie HorowitzRegeneron Genetics Center, Tarrytown, NY, USA.
Jing TangRegeneron Genetics Center, Tarrytown, NY, USA.
Jack A KosmickiRegeneron Genetics Center, Tarrytown, NY, USA.
Veera M RajagopalRegeneron Genetics Center, Tarrytown, NY, USA.
Yuxin ZouRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0001-9816-5847
Yariv HouvrasRegeneron Pharmaceuticals, Tarrytown, NY, USA.
Arkopravo GhoshRegeneron Genetics Center, Tarrytown, NY, USA.
Christopher GilliesRegeneron Genetics Center, Tarrytown, NY, USA.
Joelle MbatchouRegeneron Genetics Center, Tarrytown, NY, USA.
Ryan R WhiteRegeneron Pharmaceuticals, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0001-8344-2549
Niek VerweijRegeneron Genetics Center, Tarrytown, NY, USA.
Jonas BovijnRegeneron Genetics Center, Tarrytown, NY, USA.
Neelroop N ParikshakRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0003-2027-1871
Michelle G LeBlancRegeneron Genetics Center, Tarrytown, NY, USA.
Marcus JonesRegeneron Genetics Center, Tarrytown, NY, USA.
Regeneron Genetics Center
GHS-RGC DiscovEHR Collaboration
David J GlassRegeneron Pharmaceuticals, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0001-6187-4164
Luca A LottaRegeneron Genetics Center, Tarrytown, NY, USA.
Michael N CantorRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0002-1074-1203
Gurinder S AtwalRegeneron Pharmaceuticals, Tarrytown, NY, USA.
Adam E LockeRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0001-6227-198X
Manuel A R FerreiraRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0001-9059-1825
Raquel DeeringRegeneron Pharmaceuticals, Tarrytown, NY, USA.
Charles PauldingRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0002-7918-3561
Alan R ShuldinerRegeneron Genetics Center, Tarrytown, NY, USA.
Gavin ThurstonRegeneron Pharmaceuticals, Tarrytown, NY, USA.
Adolfo A FerrandoRegeneron Genetics Center, Tarrytown, NY, USA.
Will SalernoRegeneron Genetics Center, Tarrytown, NY, USA.
Jeffrey G ReidRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0001-8645-4713
John D OvertonRegeneron Genetics Center, Tarrytown, NY, USA.
Jonathan MarchiniRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0003-0610-8322
Hyun M KangRegeneron Genetics Center, Tarrytown, NY, USA.
Aris BarasRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0002-6830-3396
Gonçalo R AbecasisRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0003-1509-1825
Eric JorgensonRegeneron Genetics Center, Tarrytown, NY, USA. eric.jorgenson@regeneron.com.ORCID http://orcid.org/0000-0002-5829-8191
Regeneron (United States) · US

Funding

Medical Research Council MC_PC_17228Medical Research Council MC_QA137853
6 · The paper itself

Abstract

Clonal haematopoiesis involves the expansion of certain blood cell lineages and has been associated with ageing and adverse health outcomes

Indexed as

Cardiovascular DiseasesCOVID-19Clonal HematopoiesisHumans

Identifiers

PMID36450978
PMCPMC9713173
OpenAlexW4310439055

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.