ReviewJournal of neurology2023
Towards clinical application of implantable brain-computer interfaces for people with late-stage ALS: medical and ethical considerations.
Review in Journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Article
- Multimodal Assessment of Consciousness with Brain-Computer Interfaces and Artificial Intelligence: From Acquired Brain Injury to Neurodegenerative Disease.Journal of clinical medicine · 2026Review
- Reconnecting Minds to the World: Patient Perspectives on Brain-Computer Interface After High Cervical Spinal Cord Injury.Annals of rehabilitation medicine · 2026Article
- Recommendations on post-trial responsibility in implantable neural device research: a multidisciplinary consensus study.BMC medical ethics · 2026Article
- Review of electroencephalography and electromyography research in robotics: opportunities and challenges.Visual computing for industry, biomedicine, and art · 2026Review
- Current status and future prospects of brain-computer interfaces in the field of neurological disease rehabilitation.Frontiers in rehabilitation sciences · 2026Review
- Banking on My Voice: Life with Motor Neurone Disease.Healthcare (Basel, Switzerland) · 2025Article
- Signal acquisition of brain-computer interfaces: A medical-engineering crossover perspective review.Fundamental research · 2025Review
- Encephalography cross-frequency coupling and brain alteration in amyotrophic lateral sclerosis.Brain communications · 2025Article
- A review of ethical considerations for the medical applications of brain-computer interfaces.Cognitive neurodynamics · 2024Review
- [An emerging discipline: brain-computer interfaces medicine].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Review
- Advances in Brain Stimulation, Nanomedicine and the Use of Magnetoelectric Nanoparticles: Dopaminergic Alterations and Their Role in Neurodegeneration and Drug Addiction.Molecules (Basel, Switzerland) · 2024Review
- Update on recent advances in amyotrophic lateral sclerosis.Journal of neurology · 2024Review
- Developer perspectives on the ethics of AI-driven neural implants: a qualitative study.Scientific reports · 2024Article
- [Ethical considerations for medical applications of implantable brain-computer interfaces].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Article
- Biocompatible Biphasic Iontronics Enable Neuron-Like Ionic Signal Transmission.Research (Washington, D.C.) · 2024Review
- The ethical significance of user-control in AI-driven speech-BCIs: a narrative review.Frontiers in human neuroscience · 2024Review
- What stakeholders with neurodegenerative conditions value about speech and accuracy in development of BCI systems for communication.Brain computer interfaces (Abingdon, England) · 2024Article
- Enhancing learning experiences: EEG-based passive BCI system adapts learning speed to cognitive load in real-time, with motivation as catalyst.Frontiers in human neuroscience · 2024Article
- Boosting brain-computer interfaces with functional electrical stimulation: potential applications in people with locked-in syndrome.Journal of neuroengineering and rehabilitation · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
Individuals with amyotrophic lateral sclerosis (ALS) frequently develop speech and communication problems in the course of their disease. Currently available augmentative and alternative communication technologies do not present a solution for many people with advanced ALS, because these devices depend on residual and reliable motor activity. Brain-computer interfaces (BCIs) use neural signals for computer control and may allow people with late-stage ALS to communicate even when conventional technology falls short. Recent years have witnessed fast progression in the development and validation of implanted BCIs, which place neural signal recording electrodes in or on the cortex. Eventual widespread clinical application of implanted BCIs as an assistive communication technology for people with ALS will have significant consequences for their daily life, as well as for the clinical management of the disease, among others because of the potential interaction between the BCI and other procedures people with ALS undergo, such as tracheostomy. This article aims to facilitate responsible real-world implementation of implanted BCIs. We review the state of the art of research on implanted BCIs for communication, as well as the medical and ethical implications of the clinical application of this technology. We conclude that the contribution of all BCI stakeholders, including clinicians of the various ALS-related disciplines, will be needed to develop procedures for, and shape the process of, the responsible clinical application of implanted BCIs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.