Evidence map›Paper›PMID 36450891›Full record

ArticleGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2023

Comprehensive transcriptomic profiling and mutational landscape of primary gastric linitis plastica.

Zhu Liu, Lian-Lian Hong, Jin-Sen Zheng, Zhe-Nan Ling, Zhi-Long Zhang, Ya-Nan Qi, Xin-Yu Zhang, Tian-Yu Zhu, Jiu-Li Wang, Jing Han and 5 more

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Therapeutic strategy for scirrhous type gastric cancer.Japanese journal of clinical oncology · 2025
    Review
  4. Article
  5. Therapeutic strategies and prognostic challenges in linitis plastica.World journal of experimental medicine · 2025
    Article
  6. Comprehensive histopathological analysis of gastric cancer in European and Latin America populations reveals differences in PDL1, HER2, p53 and MUC6 expression.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Targeting IGF2BP3 in Cancer.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Zhu Liu *Zhejiang Cancer Institute, Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Cancer Hospital of the University of Chinese Academy of Sciences, No.1 Banshan East Rd., Gongshu District, Hangzhou, 310022, People's Republic of China.
Lian-Lian Hong *Zhejiang Cancer Institute, Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Cancer Hospital of the University of Chinese Academy of Sciences, No.1 Banshan East Rd., Gongshu District, Hangzhou, 310022, People's Republic of China.
Jin-Sen Zheng *Zhejiang Cancer Institute, Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Cancer Hospital of the University of Chinese Academy of Sciences, No.1 Banshan East Rd., Gongshu District, Hangzhou, 310022, People's Republic of China.
Zhe-Nan LingDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, People's Republic of China.
Zhi-Long ZhangDepartment of Oncology, The Second Clinical Medical College of Zhejiang, Chinese Medicine University, Hangzhou, Zhejiang Province, People's Republic of China.
Ya-Nan QiDepartment of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Xin-Yu ZhangDepartment of Oncology, The Second Clinical Medical College of Zhejiang, Chinese Medicine University, Hangzhou, Zhejiang Province, People's Republic of China.
Tian-Yu ZhuDepartment of Digestive Oncology, The First Affiliated Hospital of Wenzhou Medical University, The First Provincial Wenzhou Hospital of Zhejiang, Wenzhou, 325000, China.
Jiu-Li WangZhejiang Cancer Institute, Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Cancer Hospital of the University of Chinese Academy of Sciences, No.1 Banshan East Rd., Gongshu District, Hangzhou, 310022, People's Republic of China.
Jing HanZhejiang Cancer Institute, Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Cancer Hospital of the University of Chinese Academy of Sciences, No.1 Banshan East Rd., Gongshu District, Hangzhou, 310022, People's Republic of China.
Xiang-Liu ChenZhejiang Cancer Institute, Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Cancer Hospital of the University of Chinese Academy of Sciences, No.1 Banshan East Rd., Gongshu District, Hangzhou, 310022, People's Republic of China.
Qi-Ming YuDepartment of Gastric Surgery, Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Cancer Hospital of the University of Chinese Academy of Sciences, No.1 Banshan East Rd., Gongshu District, Hangzhou, 310022, People's Republic of China.
Shi WangDepartment of Endoscopy, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Cancer and Basic Medicine (IBMC), Chinese Academy of Sciences, Hangzhou, China.
Pei LiDepartment of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Zhi-Qiang LingZhejiang Cancer Institute, Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Cancer Hospital of the University of Chinese Academy of Sciences, No.1 Banshan East Rd., Gongshu District, Hangzhou, 310022, People's Republic of China. lingzq@zjcc.org.cn.ORCID 0000-0003-2155-1111
Cancer Hospital of Chinese Academy of Medical Sciences · CNZhejiang Chinese Medical University · CNZhengzhou University · CNWenzhou Medical University · CNZhejiang Cancer Hospital · CN

Funding

General Project from Zhejiang Provincial Natural Science Foundation LQ19H160005Key Projects from Zhejiang Provincial Natural Science Foundation LZ18H160002Leading Talents in Scientific and Technological Innovation from Zhejiang Provincial Ten Thousand Talents Plan Zhejiang Provincial CPC Committee Talents [2019]-3National Health Commission Science Research Fund-Zhejiang Provincial Health Key Science and Technology Plan Project WKJ-ZJ-2117National Natural Science Foundation of China 32271238National Natural Science Foundation of China 81972908Program for Innovation Research Team (in Science and Technology) in University of Henan Province 20IRTSTHN026Zhejiang Medical and Health Science and Technology Project 2019ZD025Zhejiang Province Health Leader Talent (Zjwjw2021-40), and Major Training Personnel from Zhejiang Provincial Program for Training and Development Project for 151 Talents Zjhrss2014-150
6 · The paper itself

Abstract

backgroundPrimary gastric linitis plastica (GLP) is a distinct phenotype of gastric cancer with poor survival. Comprehensive molecular profiles and putative therapeutic targets of GLP remain undetermined.

methodsWe subjected 10 tumor-normal tissue pairs to whole exome sequencing (WES) and whole transcriptome sequencing (WTS). 10 tumor samples were all GLP which involves 100% of the gastric wall macroscopically. TCGA data were compared to generate the top mutated genes and the overexpressed genes in GLP.

resultsOur results reveal that GLP has distinctive genomic and transcriptomic features, dysfunction in the Hippo pathway is likely to be a key step during GLP development. 6 genes were identified as significantly highly mutated genes in GLP, including AOX1, ANKRD36C, CPXM1, PTPN14, RPAP1, and DCDC1). MUC6, as a previously identified gastric cancer driver gene, has a high mutation rate (20%) in GLP. 20% of patients in our GLP cohort had CDH1 mutations, while none had RHOA mutations. GLP exhibits high immunodeficiency and low AMPK pathway activity. Our WTS results showed that 3 PI3K-AKT pathway-related genes (PIK3R2, AKT3, and IGF1) were significantly up-regulated in GLP. Two genes were identified using immunohistochemistry (IHC), IGF2BP3 and MUC16, which specifically expressed in diffuse-type-related gastric cancer cell lines, and its knockdown inhibits PI3K-AKT pathway activity.

conclusionsWe provide the first integrative genomic and transcriptomic profiles of GLP, which may facilitate its diagnosis, prognosis, and treatment.

Indexed as

Linitis PlasticaStomach NeoplasmsCarrier ProteinsHumansMutationPhosphatidylinositol 3-KinasesProtein Tyrosine Phosphatases, Non-ReceptorProto-Oncogene Proteins c-aktTranscriptomeCarrier ProteinsPhosphatidylinositol 3-KinasesProtein Tyrosine Phosphatases, Non-ReceptorProto-Oncogene Proteins c-aktPTPN14 protein, humanRPAP1 protein, humanGastric cancer (GC)Gastric linitis plastica (GLP)Scirrhous gastric cancer (SGC)Whole exome sequencing (WES)Whole transcriptome sequencing (WTS)

Identifiers

PMID36450891
PMCPMC9950178
OpenAlexW4310434328

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.