ArticleJournal of perinatology : official journal of the California Perinatal Association2023
Use of an electronic medical record to optimize a neonatal sepsis score for mortality prediction.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 3 citations in OpenAlex.
- Severe Neonatal Infection in Crisponi Syndrome: A Diagnostic Challenge in a Preterm Infant.Cureus · 2026Article
- Neonatal Sepsis as Organ Dysfunction: Prognostic Accuracy and Clinical Utility of the nSOFA in the NICU-A Systematic Review.Diagnostics (Basel, Switzerland) · 2026Review
- Construction and validation of neonatal sepsis diagnostic nomograms: a single-site retrospective study.Frontiers in pediatrics · 2026Article
- Risk prediction model for neonatal mortality among neonates hospitalized with sepsis, Bahir Dar, Ethiopia.Scientific reports · 2025Article
- Validating the performance of organ dysfunction scores in children with infection: A cohort study.PloS one · 2024Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveLate-onset sepsis (LOS) is a significant cause of mortality in preterm infants. The neonatal sequential organ failure assessment (nSOFA) provides an objective assessment of sepsis risk but requires manual calculation. We developed an EMR pipeline to automate nSOFA calculation for more granular analysis of score performance and to identify optimal alerting thresholds.
methodsInfants born <33 weeks of gestation with LOS were included. A SQL-based pipeline calculated hourly nSOFA scores 48 h before/after sepsis evaluation. Sensitivity analysis identified the optimal timing and threshold of nSOFA for LOS mortality.
resultsEighty episodes of LOS were identified (67 survivors, 13 non-survivor). Non-survivors had persistently elevated nSOFA scores, markedly increasing 12 h prior to culture. At sepsis evaluation, the AUC for nSOFA >2 was 0.744 (p = 0.0047); thresholds of >3 and >4 produced lower AUCs.
conclusionsnSOFA is persistently elevated for infants with LOS mortality compared to survivors with an optimal alert threshold >2.
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Registered trials
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