Evidence map›Paper›PMID 36450831›Full record

ArticlePsychopharmacology2023

A repeated measures cognitive affective bias test in rats: comparison with forced swim test.

Benjamin Aliphon, Twain Dai, Jessica Moretti, Marissa Penrose-Menz, Wilhelmina H A M Mulders, Dominique Blache, Jennifer Rodger

Abstract read
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In one paragraph

Article in Psychopharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Benjamin AliphonSchool of Biological Sciences, University of Western Australia, Crawley, Australia.
Twain DaiSchool of Biological Sciences, University of Western Australia, Crawley, Australia.
Jessica MorettiSchool of Biological Sciences, University of Western Australia, Crawley, Australia.
Marissa Penrose-MenzSchool of Biological Sciences, University of Western Australia, Crawley, Australia.
Wilhelmina H A M MuldersSchool of Human Sciences, University of Western Australia, 35 Stirling Highway, Crawley, WA, 6009, Australia.
Dominique BlacheSchool of Agriculture and Environment, Institute of Agriculture, University of Western Australia, Crawley, Australia.
Jennifer RodgerSchool of Biological Sciences, University of Western Australia, Crawley, Australia. Jennifer.rodger@uwa.edu.au.ORCID http://orcid.org/0000-0003-3413-4229
The University of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleThere is an urgent need to identify behaviours in animals that can provide insight into the aetiology and potential treatment of depression in humans.

objectivesThis study aimed to validate a repeated measures cognitive affective bias (CAB) test in a rat model of chronic stress and compare CAB with forced swim test (FST) measures.

methodsMale and female Sprague Dawley rats were trained to associate large and small rewards with scent, spatial, and tactile cues, and their response to an ambiguous tactile stimulus tested. Rats underwent weekly CAB testing for 4 weeks with no intervention, or for 2 weeks of chronic restraint stress (CRS), followed by 2 weeks of fluoxetine, vehicle, or no treatment. CRS rats also underwent the FST at selected timepoints.

resultsIn control rats, CAB was positive and remained stable over the 4-week period. In CRS-fluoxetine and CRS-vehicle groups, CAB was initially positive, became negative during chronic restraint stress, and returned to positive by 2 weeks after treatment. However, in the CRS-no treatment group, CAB was variable at the outset and unstable over time. Behaviour in the FST was not affected by treatment, and there was no correlation between CAB and FST outcomes.

conclusionsInstability in the CRS-no treatment group precluded interpretation of the impact of fluoxetine on CAB post-CRS. Our results suggest that behaviour in the FST does not reflect or alter affective state and support the use of CAB tests as part of the behavioural testing repertoire for preclinical animal models of affective disorders.

Indexed as

Animal welfareAntidepressantCognitive affective biasForced swim testMood disordersRodent models

Identifiers

PMID36450831
OpenAlexW4310570498

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.