Evidence map›Paper›PMID 36450821›Full record

Trial reportScientific reports2022

Part three: a randomized study to assess biomarker changes in cigarette smokers switched to Vuse Solo or Abstinence.

Milly N Kanobe, Bobbette A Jones, Paul Nelson, Buddy G Brown, Peter Chen, Patrudu Makena, Eckhardt Schmidt, John Darnell, John W Caraway, G L Prasad and 2 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 4 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 4 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Electronic cigarettes for smoking cessation.The Cochrane database of systematic reviews · 2026
    Pooled it
  2. Electronic cigarettes for smoking cessation.The Cochrane database of systematic reviews · 2025
    Pooled it
  3. Electronic cigarettes for smoking cessation.The Cochrane database of systematic reviews · 2025
    Pooled it
  4. Electronic cigarettes for smoking cessation.The Cochrane database of systematic reviews · 2024
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Milly N KanobeRAI Services Company, 401 N. Main Street, Winston-Salem, NC, 27101, USA. kanobem@rjrt.com.
Bobbette A JonesRAI Services Company, 401 N. Main Street, Winston-Salem, NC, 27101, USA.
Paul NelsonRAI Services Company, 401 N. Main Street, Winston-Salem, NC, 27101, USA.
Buddy G BrownRAI Services Company, 401 N. Main Street, Winston-Salem, NC, 27101, USA.
Peter ChenRAI Services Company, 401 N. Main Street, Winston-Salem, NC, 27101, USA.
Patrudu MakenaRAI Services Company, 401 N. Main Street, Winston-Salem, NC, 27101, USA.
Eckhardt SchmidtRAI Services Company, 401 N. Main Street, Winston-Salem, NC, 27101, USA.
John DarnellRAI Services Company, 401 N. Main Street, Winston-Salem, NC, 27101, USA.
John W CarawayRAI Services Company, 401 N. Main Street, Winston-Salem, NC, 27101, USA.
G L PrasadRAI Services Company, 401 N. Main Street, Winston-Salem, NC, 27101, USA.
Brian NordskogJTI Leaf Services (US) LLC, 202 Stinson Drive, Danville, VA, 24540, USA.
Elaine K RoundRAI Services Company, 401 N. Main Street, Winston-Salem, NC, 27101, USA.
Research Applications (United States) · USScientific Consulting Group · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biomarkers of exposure (BoE) can help evaluate exposure to combustion-related, tobacco-specific toxicants after smokers switch from cigarettes to potentially less-harmful products like electronic nicotine delivery systems (ENDS). This paper reports data for one (Vuse Solo Original) of three products evaluated in a randomized, controlled, confinement study of BoE in smokers switched to ENDS. Subjects smoked their usual brand cigarette ad libitum for two days, then were randomized to one of three ENDS for a 7-day ad libitum use period, or to smoking abstinence. Thirteen BoE were assessed at baseline and Day 5, and percent change in mean values for each BoE was calculated. Biomarkers of potential harm (BoPH) linked to oxidative stress, platelet activation, and inflammation were also assessed. Levels decreased among subjects randomized to Vuse Solo versus Abstinence, respectively, for the following BoE: 42-96% versus 52-97% (non-nicotine constituents); 51% versus 55% (blood carboxyhemoglobin); and 29% versus 96% (nicotine exposure). Significant decreases were observed in three BoPH: leukotriene E4, 11-dehydro-thromboxane B2, and 2,3-dinor thromboxane B2 on Day 7 in the Vuse Solo and Abstinence groups. These findings show that ENDS use results in substantially reduced exposure to toxicants compared to smoking, which may lead to reduced biological effects.

Indexed as

Electronic Nicotine Delivery SystemsTobacco ProductsBiomarkersHazardous SubstancesHumansSmokersSmokingBiomarkersHazardous Substances

Identifiers

PMID36450821
PMCPMC9712618
OpenAlexW4310643885

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.