ArticleScientific reports2022
Blunted rest-activity circadian rhythm increases the risk of all-cause, cardiovascular disease and cancer mortality in US adults.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Sleep-Aligned Extended Overnight Fasting Improves Nighttime and Daytime Cardiometabolic Function.Arteriosclerosis, thrombosis, and vascular biology · 2026Trial
- Enhancing a Behavioral Intervention Using Rest-Activity Rhythm Monitoring via a Consumer Wearable in Older Dementia Caregivers and People With Dementia: Feasibility and Acceptability Study.JMIR formative research · 2026Article
- Longitudinal digital phenotyping of activity rhythms and biological aging using commercial wearables.Nature communications · 2026Article
- Associations of sleep duration, physical activity, and longitudinal changes with the risk of fatal stroke occurrence in middle-aged to older individuals : Physical activity, sleep duration, and risk of fatal stroke.BMC public health · 2026Article
- Association of physical activity and rest-activity rhythm with sustained attention and melatonin among community-dwelling older adults.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2026Article
- Association of Rest-Activity Rhythm and Sleep Regularity With Cardiometabolic Disease in the CARDIA Study.Journal of the American Heart Association · 2026Article
- Circadian rest/activity rhythms and change in MRI-derived brain volumes: Differences by age in a cognitively healthy sample.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Rest-activity rhythms and cardiovascular events in cardiovascular-kidney-metabolic syndrome: evidence from two nationwide cohorts.American journal of preventive cardiology · 2026Article
- Article
- Observational
- Circadian disruption is associated with advanced cardio-kidney-metabolic syndrome in overweight and obese adults: evidence from the NHANES database.Nutrition & metabolism · 2026Article
- Accelerometer-derived rest-activity rhythms, genetic risk, and chronic inflammatory markers and the risk of abdominal aortic aneurysm.Frontiers in public health · 2026Article
- Exploring person-centred sleep and rest-activity cycle dynamics over 6 months.Journal of sleep research · 2025Article
- Sleep and Rest-Activity Rhythms are Delayed and Less Robust in People Living With HIV.Open forum infectious diseases · 2025Article
- Sleep Irregularity, Circadian Disruption, and Cardiometabolic Disease Risk.Circulation research · 2025Review
- Circadian syndrome and mortality risk in adults aged ≥ 40 years: a prospective cohort analysis of CHARLS and NHANES.Scientific reports · 2025Article
- Circadian rest-activity rhythms and multimorbidity and mortality risks among menopausal women: a trajectory analysis of a UK Biobank cohort.BMC public health · 2025Article
- Effects of caffeine on accelerometer measured sleep and physical activity among older adults under free-living conditions.BMC public health · 2024Article
- The association of 24-hour behavior rhythms with stroke among American adults with prediabetes/diabetes: evidence from NHANES 2011-2014.BMC public health · 2024Article
- Reliable measures of rest-activity rhythm fragmentation: how many days are needed?European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
To examine whether rest-activity circadian rhythm parameters can predict all-cause, cardiovascular disease and cancer mortality in a general adult population of the US. We further compared the mortality predictive performance of these parameters with that of traditional risk factors. This study included 7,252 adults from US National Health and Nutrition Examination Surveys (NHANES) 2011-2014, who had wrist accelerometer data obtained at baseline and follow-up status linked to the National Death Index records (2011-2019). During a median of 81 months (interquartile range, 69-94 months) of follow-up, 674 (9.3%) deaths occurred. There were inverse associations between relative amplitude (RA) and all-cause mortality, cardiovascular disease and cancer mortality with increased quartiles RA associated with lower mortality risk (all P < 0.05). The Hazard Ratios ranged from 0.61 to 0.79. Furthermore, RA outperformed all the tested traditional predictors of all-cause mortality with the exception of age. This study suggests that participants with blunted rest-activity circadian rhythms had a higher risk of all-cause, cardiovascular disease and cancer mortality. Future studies will be needed to test whether interventions that regulate rest-activity circadian activity rhythms will improve health outcomes.
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