ArticleBMJ open2022
Comorbidities in patients with migraine in Japan: a cross-sectional study using data from National Health and Wellness Survey.
Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 11 citations in OpenAlex.
- Real-World Characteristics and Treatment Patterns of Calcitonin Gene-Related Peptide Monoclonal Antibody Users: a Japanese Claims Database-Based Study.Pain and therapy · 2026Article
- Clinical and social burden of migraine in Japanese males: a cross-sectional comparison with females without menstrual migraine.The journal of headache and pain · 2026Article
- High prevalence of primary headaches among patients with post-traumatic stress disorder: an observational study of consecutive patients.The journal of headache and pain · 2025Observational
- Prevalence, Treatment, and Unmet Needs of Migraine in the Middle East: A Systematic Review.Pain and therapy · 2025Review
- The Gut-brain Connection and Episodic Migraine: an Update.Current pain and headache reports · 2023Review
- Article
- Depression and anxiety in Chinese patients hospitalized with primary headache: A cross-sectional multicenter study.Molecular painArticle
- Psychiatric comorbidity in patients with migraine: A standardized interview-based study.Industrial psychiatry journalArticle
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aims to examine the association between migraine and various psychiatric and somatic comorbidities in Japan.
designCross-sectional study using existing data of the 2017 Japan National Health and Wellness Survey (NHWS).
settingNationally representative sample of persons (in terms of age and gender) living in the general community aged 18 years or older in Japan.
participantsOut of a sample of 30 001 NHWS respondents, 378 respondents were identified as migraine patients and 25 209 were identified as non-migraine patients. After propensity score (PS) matching (1:4), 1512 matched non-migraine respondents were identified. PRIMARY AND SECONDARY OUTCOME MEASURES: Prevalence and PS-matched prevalence ORs (PORs) were assessed for each psychiatric and somatic comorbidity among migraine patients and matched non-migraine respondents (including migraine patients with less than 15 monthly headache days (MHDs) and migraine patients with more than 15 MHDs).
resultsMigraine patients were predominately female and had significantly higher prevalence than matched non-migraine respondents to have psychiatric and somatic comorbidities. Psychiatric comorbidities with >5% prevalence among migraine patients included depression, post-traumatic stress disorder and anxiety disorders, while gastrointestinal disorders were the most prevalent somatic comorbidity category. Other somatic comorbidities included allergies, insomnia, premenstrual syndrome and anaemia. Migraine patients with more than 15 MHDs tended to have higher point estimates for POR.
conclusionPsychiatric and somatic conditions were more prevalent in migraine patients than matched non-migraine respondents, some being novel associations not previously reported in Japan. This study provided insights on comorbidities, which could complicate care, clinical practice and outcomes among migraine patients.
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