Evidence map›Paper›PMID 36450357›Full record

ArticleNature2023

Two broadly conserved families of polyprenyl-phosphate transporters.

Ian J Roney, David Z Rudner

Open access · greenAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
  2. Review
  3. ThemBio · 2026
    Article
  4. Review
  5. Review
  6. ThebioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Article
  9. Characterization ofJournal of the American Society for Mass Spectrometry · 2025
    Article
  10. Peptidoglycan polymerase function and regulation.Microbiology and molecular biology reviews : MMBR · 2025
    Review
  11. Article
  12. LipoproteinmBio · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. PgpP is a broadly conserved phosphatase required for phosphatidylglycerol lipid synthesis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  17. Article
  18. Review
  19. Review
  20. Lipopeptide antibiotics disrupt interactions of undecaprenyl phosphate with UptA.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ian J RoneyDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3320-1170
David Z RudnerDepartment of Microbiology, Harvard Medical School, Boston, MA, USA. rudner@hms.harvard.edu.ORCID http://orcid.org/0000-0002-0236-7143
Harvard University · US

Funding

Targeting bacterial cell wall biogenesis for the development of novel antimicrobU19AI109764 · NIAID · HARVARD MEDICAL SCHOOL · PI BELTZ, GERALD A · 2014 to 2018
$25.2M
Project 3: Defining and defeating the mechanisms of outer membrane biogenesis in Gram-negative bacteriaU19AI158028 · NIAID · HARVARD MEDICAL SCHOOL · PI WALKER, SUZANNE · 2022 to 2025
$10.1M
Chromosome Dynamics in Bacillus SubtillsR01GM086466 · NIGMS · HARVARD MEDICAL SCHOOL · PI RUDNER, DAVID Z · 2009 to 2021
$4.2M
Growth and differentiation in Bacillus subtilisR35GM145299 · NIGMS · HARVARD MEDICAL SCHOOL · PI DAVID Z RUDNER · 2022 to 2026
$2.9M
Cell Envelope Homeostasis in Bacillus subtilisR01GM127399 · NIGMS · HARVARD MEDICAL SCHOOL · PI RUDNER, DAVID Z · 2019 to 2022
$1.4M
NIAID NIH HHS U19 AI109764NIAID NIH HHS U19 AI158028NIGMS NIH HHS R01 GM086466NIGMS NIH HHS R01 GM127399NIGMS NIH HHS R35 GM145299
6 · The paper itself

Abstract

Peptidoglycan and almost all surface glycopolymers in bacteria are built in the cytoplasm on the lipid carrier undecaprenyl phosphate (UndP)

Indexed as

Bacterial ProteinsCarrier ProteinsConserved SequenceEvolution, MolecularGram-Negative BacteriaGram-Positive BacteriaPolyisoprenyl PhosphatesAnti-Bacterial AgentsBacillus subtilisCell MembraneCell WallLipopeptidesPeptidoglycanSyntenyamphomycinAnti-Bacterial AgentsBacterial ProteinsCarrier ProteinsLipopeptidesPeptidoglycanPolyisoprenyl Phosphatesundecaprenyl phosphate

Identifiers

PMID36450357
PMCPMC10184681
OpenAlexW4310570350

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.