Evidence map›Paper›PMID 36450323›Full record

ArticleVirologica Sinica2023

Taurolidine improved protection against highly pathogenetic avian influenza H5N1 virus lethal-infection in mouse model by regulating the NF-κB signaling pathway.

Chaoxiang Lv, Yuanguo Li, Tiecheng Wang, Qiqi Zhang, Jing Qi, Mingwei Sima, Entao Li, Tian Qin, Zhuangzhuang Shi, Fangxu Li and 8 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virologica Sinica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 1 country.

Chaoxiang LvCollege of Life Sciences, Northeast Normal University, Changchun, Jilin, 130021, China; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences. Changchun, 130122, China.
Yuanguo LiChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences. Changchun, 130122, China; College of Animal Medicine, Jilin University, Changchun, 130000, China.
Tiecheng WangChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences. Changchun, 130122, China.
Qiqi ZhangCollege of Life Sciences, Northeast Normal University, Changchun, Jilin, 130021, China.
Jing QiCollege of Life Sciences, Northeast Normal University, Changchun, Jilin, 130021, China; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences. Changchun, 130122, China.
Mingwei SimaChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences. Changchun, 130122, China; College of Basic Medicine, Changchun University of Chinese Medicine, Changchun, 130117, China.
Entao LiChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences. Changchun, 130122, China.
Tian QinCollege of Life Sciences, Northeast Normal University, Changchun, Jilin, 130021, China; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences. Changchun, 130122, China.
Zhuangzhuang ShiChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences. Changchun, 130122, China; College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130033, China.
Fangxu LiChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences. Changchun, 130122, China; College of Life Sciences, Shandong Normal University, Jinan, 250014, China.
Xuefeng WangChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences. Changchun, 130122, China.
Weiyang SunChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences. Changchun, 130122, China.
Na FengChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences. Changchun, 130122, China.
Songtao YangChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences. Changchun, 130122, China.
Xianzhu XiaChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences. Changchun, 130122, China.
Ningyi JinCollege of Life Sciences, Northeast Normal University, Changchun, Jilin, 130021, China; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences. Changchun, 130122, China; College of Basic Medicine, Changchun University of Chinese Medicine, Changchun, 130117, China; College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130033, China. Electronic address: ningyik@126.com.
Yifa ZhouCollege of Life Sciences, Northeast Normal University, Changchun, Jilin, 130021, China. Electronic address: zhouyf383@nenu.edu.cn.
Yuwei GaoChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences. Changchun, 130122, China; College of Basic Medicine, Changchun University of Chinese Medicine, Changchun, 130117, China; College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130033, China; College of Life Sciences, Shandong Normal University, Jinan, 250014, China. Electronic address: gaoyuwei@gmail.com.
Chinese Academy of Agricultural Sciences · CNNortheast Normal University · CNChangchun Normal University · CNChangchun University of Chinese Medicine · CNJilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Taurolidine (TRD), a derivative of taurine, has anti-bacterial and anti-tumor effects by chemically reacting with cell-walls, endotoxins and exotoxins to inhibit the adhesion of microorganisms. However, its application in antiviral therapy is seldom reported. Here, we reported that TRD significantly inhibited the replication of influenza virus H5N1 in MDCK cells with the half-maximal inhibitory concentration (EC

Indexed as

Influenza A virusInfluenza A Virus, H5N1 SubtypeInfluenza in BirdsOrthomyxoviridae InfectionsAnimalsAntiviral AgentsMiceMice, Inbred BALB CNF-kappa BSignal TransductionTaurineThiadiazinesVirus ReplicationAntiviral AgentsNF-kappa BTaurinetaurolidineThiadiazinesCytokine stormsH5N1Inflammatory responseInfluenza virusesNF-κB signaling pathwayTaurolidine (TRD)

Identifiers

PMID36450323
PMCPMC10006309
OpenAlexW4310261789

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.