Evidence map›Paper›PMID 36450280›Full record

ArticleNeurocase2022

Visual and social differences in dyslexia: deep phenotyping of four cases with spared phonology.

Eleanor R Palser, Zachary A Miller, Abigail E Licata, Nicole A Yabut, Swati P Sudarsan, Boon Lead Tee, Jessica A Deleon, Maria Luisa Mandelli, Eduardo Caverzasi, Virginia E Sturm and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurocase, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Eleanor R PalserDepartment of Neurology, University of California, San Francisco, CA, USA.
Zachary A MillerDepartment of Neurology, University of California, San Francisco, CA, USA.
Abigail E LicataDepartment of Neurology, University of California, San Francisco, CA, USA.
Nicole A YabutDepartment of Neurology, University of California, San Francisco, CA, USA.
Swati P SudarsanDepartment of Neurology, University of California, San Francisco, CA, USA.
Boon Lead TeeDepartment of Neurology, University of California, San Francisco, CA, USA.ORCID 0000-0003-2217-3466
Jessica A DeleonDepartment of Neurology, University of California, San Francisco, CA, USA.
Maria Luisa MandelliDepartment of Neurology, University of California, San Francisco, CA, USA.
Eduardo CaverzasiDepartment of Neurology, University of California, San Francisco, CA, USA.
Virginia E SturmDepartment of Neurology, University of California, San Francisco, CA, USA.
Robert HendrenDyslexia Center, University of California, San Francisco, CA, USA.
Katherine L PossinDepartment of Neurology, University of California, San Francisco, CA, USA.
Bruce L MillerDepartment of Neurology, University of California, San Francisco, CA, USA.
Maria Luisa Gorno TempiniDepartment of Neurology, University of California, San Francisco, CA, USA.
Christa Watson PereiraDepartment of Neurology, University of California, San Francisco, CA, USA.
University of California, San Francisco · US

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Progressive Aphasia Cognition Anatomy and ProgressionR01NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI · 2004 to 2026
$11.0M
Training program in the neurology of language and neurodegenerative aphasiasK24DC015544 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2016 to 2025
$1.9M
Primary Progressive Aphasia: Beyond the Clinical VariantsK23DC018021 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DELEON, JESSICA ANNE · 2020 to 2024
$995k
Chinese Language Assessment in Primary Progressive AphasiaR21AG068757 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2021 to 2022
$360k
NIA NIH HHS P01 AG019724NIA NIH HHS R21 AG068757NIDCD NIH HHS K23 DC018021NIDCD NIH HHS K24 DC015544NINDS NIH HHS R01 NS050915
6 · The paper itself

Abstract

Diagnostic criteria for dyslexia describe specific reading difficulties, and single-deficit models, including the phonological deficit theory, have prevailed. Children seeking diagnosis, however, do not always show phonological deficits, and may present with strengths and challenges beyond reading. Through extensive neurological, neuropsychological, and academic evaluation, we describe four children with visuospatial, socio-emotional, and attention impairments and spared phonology, alongside long-standing reading difficulties. Diffusion tensor imaging revealed white matter alterations in inferior longitudinal, uncinate, and superior longitudinal fasciculi versus neurotypical children. Findings emphasize that difficulties may extend beyond reading in dyslexia and underscore the value of deep phenotyping in learning disabilities.

Indexed as

DyslexiaWhite MatterChildDiffusion Tensor ImagingHumansPhoneticsReadingcase seriescomorbidityNeurodevelopmentreadingspecific learning disability

Identifiers

PMID36450280
PMCPMC9957930
OpenAlexW4310471225

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.