Evidence map›Paper›PMID 36449173›Full record

ArticlePharmacoEconomics2023

Estimating the Relationship Between EQ-5D-5L and EQ-5D-3L: Results from a UK Population Study.

Mónica Hernández Alava, Steve Pudney, Allan Wailoo

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PharmacoEconomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07580092 (Construct Validity and Responsiveness of EQ-5D-3L and EQ-5D-5L in Patients With Inflammatory Joint Disease), which is not on this map. Cited by 131 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07580092 completednot on this map

Construct Validity and Responsiveness of EQ-5D-3L and EQ-5D-5L in Patients With Inflammatory Joint Disease

TypeobservationalSponsorKarolinska InstitutetRan2023 to 2026Enrolled6,967ConditionsAnkylosing Spondylitis, Rheumatoid Arthritis (RA), Psoriatic Arthritis, PolyarthritisArmsEQ-5D-5L
3 · Its place in the literature

Who cites it

131 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  4. Impact of Choice of Tariff When Calculating Clinically Meaningful EQ-5D Scores in Metabolic Dysfunction-Associated Steatohepatitis.Liver international : official journal of the International Association for the Study of the Liver · 2025
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71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mónica Hernández AlavaSchool of Health and Related Research, University of Sheffield, Sheffield, S1 4DA, UK.
Steve PudneySchool of Health and Related Research, University of Sheffield, Sheffield, S1 4DA, UK.
Allan WailooSchool of Health and Related Research, University of Sheffield, Sheffield, S1 4DA, UK. a.j.wailoo@sheffield.ac.uk.ORCID 0000-0002-9324-1617

Funding

Department of Health
6 · The paper itself

Abstract

objectivesThe aim of this study was to estimate the relationship between EQ-5D-3L and EQ-5D-5L, in both directions, using a single model.

methodsAn online survey containing both variants of EQ-5D, with randomised ordering, was administered to a large UK sample in 2020. A joint statistical model of the ten EQ-5D responses (five at 5L, five at 3L), using a multi-equation ordinal regression framework was estimated. The joint model ensures mappings in either direction are fully consistent with the information in the sample and satisfy Bayes' rule. Three extensions enhance model flexibility: a copula specification allows differing degrees of correlation between the 3L and 5L responses at the upper and lower extremes of health; a normal mixture residual distribution gives flexibility in the distributional form of responses; and a common factor captures correlations in responses across the five dimensions.

resultsAlmost 50,000 responses were received. Thirty-five percent of respondents reported an existing medical condition. Ninety percent of possible 3L and 43% of possible 5L health states were observed. The preferred model specification includes age, sex and the responses to the EQ-5D instrument. Close alignment to the observed data was observed both in within-sample and out-of-sample comparisons.

conclusionThe results from this study provide a means of translating evidence to or from EQ-5D-3L to or from 5L based on a large-scale UK population survey with randomised ordering. Mapping can be performed either using descriptive system responses, individual utility scores or summary statistics.

Indexed as

Health StatusQuality of LifeBayes TheoremHumansPsychometricsReproducibility of ResultsSurveys and QuestionnairesUnited Kingdom

Identifiers

PMID36449173
PMCPMC9883358

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.