Evidence map›Paper›PMID 36449105›Full record

ArticlePediatric surgery international2022

Differentiation of enteric neural crest cells transplanted from SOX10-Venus mouse embryonic stem cells into the gut of the endothelin receptor B null mouse model.

Naho Fujiwara, Katsumi Miyahara, Nana Nakazawa-Tanaka, Yoshie Oishi, Chihiro Akazawa, Norihiro Tada, Atsuyuki Yamataka

Abstract read
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In one paragraph

Article in Pediatric surgery international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Naho FujiwaraDepartment of Pediatric General and Urogenital Surgery, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. naho@juntendo.ac.jp.
Katsumi MiyaharaDepartment of Pediatric General and Urogenital Surgery, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Nana Nakazawa-TanakaDepartment of Pediatric General and Urogenital Surgery, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Yoshie OishiMedical Technology Innovation Center, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan.
Chihiro AkazawaIntractable Disease Research Center, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan.
Norihiro TadaAtopy Research Center, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan.
Atsuyuki YamatakaDepartment of Pediatric General and Urogenital Surgery, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Juntendo University · JPJuntendo University Nerima Hospital · JP

Funding

Japan Society for the Promotion of Science 22K08721
6 · The paper itself

Abstract

purposeFailure of enteric neural crest-derived cells (ENCCs) to correctly colonize the embryonic gut results in Hirschsprung's disease (HD). Embryonic stem cells (ESCs) have the potential to differentiate into all tissue-specific cells and lineages, including ENCCs. We investigated the cellular differentiation of ESCs from Sox10-Venus

methodsWe established ESCs from Sox10-Venus

resultsConfocal microscopy revealed that transplanted Sox10-Venu

conclusionsThis study demonstrated that an appropriate host environment is crucial for normal and complete colonization of the gut. Further investigations are required to confirm whether modifying this environment can improve the results of this model.

Indexed as

Hirschsprung DiseaseAnimalsBacterial ProteinsCell DifferentiationDisease Models, AnimalIntestine, SmallLuminescent ProteinsMiceMice, KnockoutMouse Embryonic Stem CellsNeural CrestReceptor, Endothelin BReceptors, EndothelinSOXE Transcription FactorsBacterial ProteinsEDNRB protein, mouseLuminescent ProteinsReceptor, Endothelin BReceptors, EndothelinSox10 protein, mouseSOXE Transcription Factorsyellow fluorescent protein, BacteriaCell therapyEmbryonic stem cellsEnteric nervous systemEnteric neural crest-derived cellsHirschsprung’s diseaseSox10-Venus mice

Identifiers

PMID36449105
OpenAlexW4310775733

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.