Evidence map›Paper›PMID 36449101›Full record

ArticlePediatric nephrology (Berlin, Germany)2023

Long-term outcomes after pre-emptive liver transplantation in primary hyperoxaluria type 1.

Hadas Shasha-Lavsky, Aviv Avni, Ziv Paz, Limor Kalfon, Amiel A Dror, Orly Yakir, Tzipora Falik Zaccai, Irith Weissman

Abstract read
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In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hadas Shasha-LavskyPediatric Nephrology Unit, Galilee Medical Center, Nahariya, Israel. hadasl2@gmc.gov.il.ORCID http://orcid.org/0000-0002-1383-8000
Aviv AvniAzrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
Ziv PazAzrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
Limor KalfonInstitute of Human Genetics, Galilee Medical Center, Nahariya, Israel.
Amiel A DrorAzrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
Orly YakirStatistics Unit, Galilee Medical Center, Nahariya, Israel.
Tzipora Falik ZaccaiAzrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
Irith WeissmanPediatric Nephrology Unit, Galilee Medical Center, Nahariya, Israel.
Bar-Ilan University · ILWestern Galilee Hospital · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrimary hyperoxaluria type 1 (PH1) is an autosomal recessive disease caused by the liver defect of oxalate metabolism, which leads to kidney failure and systemic manifestations. Until recently, liver transplantation was the only definitive treatment. The timing of liver transplantation can be early, while kidney function is still normal (pre-emptive liver transplantation-PLT), or when the patient reaches stage 5 chronic kidney disease (CKD) and needs combined liver-kidney transplantation. We aimed to determine the long-term kidney outcomes of PLT in PH1 patients.

methodsA retrospective single-center study of PH1 patients who were followed in our center between 1997 and 2017. We compared the kidney outcomes of patients who underwent PLT to those who presented with preserved kidney function and did not undergo PLT.

resultsOut of 36 PH1 patients, 18 patients were eligible for PLT (eGFR > 40 mL/min/1.73 m

conclusionsPre-emptive liver transplantation preserved kidney function in patients with PH1 in our cohort. Early intervention can prevent kidney failure and systemic oxalosis in PH1. A higher resolution version of the Graphical abstract is available as Supplementary information.

Indexed as

Hyperoxaluria, PrimaryKidney Failure, ChronicLiver TransplantationRenal InsufficiencyHumansRetrospective StudiesKidney transplantationOxalatePre-emptive liver transplantation (PLT)Primary hyperoxaluria type 1 (PH1)

Identifiers

PMID36449101
OpenAlexW4310458221

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.