ArticleeLife2022
Oscillations support short latency co-firing of neurons during human episodic memory formation.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- A Synchronization-Driven Learning Rule for Pattern Separation in Self-Organizing Probabilistic Spiking Neural Networks.Research square · 2026Article
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- Human neuronal firing varies with the frequency of local field potential oscillations.PLoS biology · 2026Article
- It's not just the phase: Frequency-dependent tuning of neuronal firing.PLoS biology · 2026Article
- Human hippocampal theta-gamma coupling coordinates sequential planning during navigation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Gamma tACS over the prefrontal and parietal cortices enhances episodic memory performance.Frontiers in human neuroscience · 2026Article
- Synaptic Synchronization-Based Learning of Pattern Separation in Self-Organizing Probabilistic Spiking Neural Networks.bioRxiv : the preprint server for biology · 2025Article
- Human neuronal firing is modulated by the frequency of local field potential oscillations.bioRxiv : the preprint server for biology · 2025Article
- Models of human hippocampal specialization: a look at the electrophysiological evidence.Trends in cognitive sciences · 2025Review
- Synchronous Theta Networks Characterize Successful Memory Retrieval.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Sequential Activation of Lateral Hypothalamic Neuronal Populations during Feeding and Their Assembly by Gamma Oscillations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Reactivation strength during cued recall is modulated by graph distance within cognitive maps.eLife · 2024Article
- Commentary on "Synchronized activity of sensory neurons initiates cortical synchrony in a model of neuropathic pain".Neural regeneration research · 2024Article
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- Interaction between Theta Phase and Spike Timing-Dependent Plasticity Simulates Theta-Induced Memory Effects.eNeuro · 2023Article
- What happens in the brain when we die? Deciphering the neurophysiology of the final moments in life.Frontiers in aging neuroscience · 2023Review
- Oscillations support short latency co-firing of neurons during human episodic memory formation.eLife · 2022Article
- The Same Ultra-Rapid Parallel Brain Dynamics Underpin the Production and Perception of Speech.Cerebral cortex communications · 2021Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 3 countries.
Funding
Abstract
Theta and gamma oscillations in the medial temporal lobe are suggested to play a critical role for human memory formation via establishing synchrony in neural assemblies. Arguably, such synchrony facilitates efficient information transfer between neurons and enhances synaptic plasticity, both of which benefit episodic memory formation. However, to date little evidence exists from humans that would provide direct evidence for such a specific role of theta and gamma oscillations for episodic memory formation. Here, we investigate how oscillations shape the temporal structure of neural firing during memory formation in the medial temporal lobe. We measured neural firing and local field potentials in human epilepsy patients via micro-wire electrode recordings to analyze whether brain oscillations are related to co-incidences of firing between neurons during successful and unsuccessful encoding of episodic memories. The results show that phase-coupling of neurons to faster theta and gamma oscillations correlates with co-firing at short latencies (~20-30 ms) and occurs during successful memory formation. Phase-coupling at slower oscillations in these same frequency bands, in contrast, correlates with longer co-firing latencies and occurs during memory failure. Thus, our findings suggest that neural oscillations play a role for the synchronization of neural firing in the medial temporal lobe during the encoding of episodic memories.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.