Evidence map›Paper›PMID 36448463›Full record

ReviewHypertension (Dallas, Tex. : 1979)2023

Toward Precision Medicine: Circadian Rhythm of Blood Pressure and Chronotherapy for Hypertension - 2021 NHLBI Workshop Report.

Michelle L Gumz, Daichi Shimbo, Marwah Abdalla, Ravi C Balijepalli, Christian Benedict, Yabing Chen, David J Earnest, Karen L Gamble, Scott R Garrison, Ming C Gong and 18 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Hypertension (Dallas, Tex. : 1979), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Chronotherapy for Hypertension: A Meta-Analysis and Systematic Review of RCTs.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2025
    Pooled it
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  12. Observational
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  15. The Japanese Society of Hypertension Guidelines for the management of elevated blood pressure and hypertension 2025 (JSH2025).Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Michelle L GumzDepartment of Physiology and Aging; Center for Integrative Cardiovascular and Metabolic Disease, Department of Medicine, Division of Nephrology, Hypertension and Renal Transplantation, University of Florida, Gainesville, FL (M.L.G.).ORCID 0000-0002-1342-0878
Daichi ShimboDepartment of Medicine, The Columbia Hypertension Center, Columbia University Irving Medical Center, New York, NY (D.S.).ORCID 0000-0001-6302-8834
Marwah AbdallaDepartment of Medicine, Center for Behavioral Cardiovascular Health, Columbia University Irving Medical Center, New York, NY (M.A.).
Ravi C BalijepalliDivision of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD (R.C.B., Y.H., J.W., Y.S.O.).
Christian BenedictDepartment of Pharmaceutical Biosciences, Molecular Neuropharmacology, Uppsala University, Sweden (C.B.).ORCID 0000-0002-8911-4068
Yabing ChenDepartment of Pathology, University of Alabama at Birmingham, and Research Department, Birmingham VA Medical Center, AL (Y.C.).ORCID 0000-0001-9676-6657
David J EarnestDepartment of Neuroscience & Experimental Therapeutics, Texas A&M University, Bryan, TX (D.J.E.).
Karen L GambleDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, AL (K.L.G.).ORCID 0000-0003-3813-8577
Scott R GarrisonDepartment of Family Medicine, University of Alberta, Canada (S.R.G.).ORCID 0000-0002-7024-2158
Ming C GongDepartment of Physiology, University of Kentucky, Lexington, KY (M.C.G.).ORCID 0000-0002-3554-7378
John B HogeneschDepartment of Pediatrics, University of Cincinnati, OH (J.B.H.).
Yuling HongDivision of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD (R.C.B., Y.H., J.W., Y.S.O.).
Jessica R IvyUniversity/British Heart Foundation Centre for Cardiovascular Science, The Queen's Medical Research Institute, The University of Edinburgh, United Kingdom (J.R.I.).ORCID 0000-0003-1004-4376
Bina JoeDepartment of Physiology and Pharmacology and Center for Hypertension and Precision Medicine, University of Toledo College of Medicine and Life Sciences, OH (B.J.).ORCID 0000-0002-2385-7061
Aaron D LaposkyNational Center on Sleep Disorders Research, Division of Lung Diseases, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD (A.D.L.).
Mingyu LiangCenter of Systems Molecular Medicine, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI (M.L.).ORCID 0000-0002-6970-989X
Eric J MacLaughlinDepartment of Pharmacy Practice, Texas Tech University Health Sciences Center, Amarillo, TX (E.J.M.).ORCID 0000-0002-1460-445X
Tami A MartinoCenter for Cardiovascular Investigations, Department of Biomedical Sciences, University of Guelph, Ontario, Canada (T.A.M.).
David M PollockDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, AL (D.M.P.).ORCID 0000-0002-0233-2362
Susan RedlineDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.R.).ORCID 0000-0002-6585-1610
Amy RogersDivision of Molecular and Clinical Medicine, University of Dundee, United Kingdom (A.R.).ORCID 0000-0001-5207-7032
R Dan RudicDepartment of Pharmacology and Toxicology, Augusta University, GA (R.D.R.).ORCID 0000-0001-9122-3127
Eva S SchernhammerChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (E.S.S.).
George S StergiouHypertension Center, STRIDE-7, National and Kapodistrian University of Athens, School of Medicine, Third Department of Medicine, Sotiria Hospital, Athens, Greece (G.S.S.).ORCID 0000-0002-6132-0038
Marie-Pierre St-OngeDivision of General Medicine, Department of Medicine, Columbia University Irving Medical Center' New York, NY (M.-P.S.-O.).ORCID 0000-0003-1354-1749
Xiaoling WangGeorgia Prevention Institute, Department of Medicine, Augusta University, GA (X.W.).
Jacqueline WrightDivision of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD (R.C.B., Y.H., J.W., Y.S.O.).
Young S OhDivision of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD (R.C.B., Y.H., J.W., Y.S.O.).

Funding

Mechanisms addressing the causal relationships of sleep, circadian rhythms, and cardiometabolic healthR35HL155670 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARIE-PIERRE ST-ONGE · 2021 to 2026
$5.4M
Impact of circadian misalignment on energy balance regulationR01HL142648 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ST-ONGE, MARIE-PIERRE · 2018 to 2022
$3.8M
Timing of sodium intake and nocturnal sodium excretion and blood pressure in obese African AmericansR01HL144716 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUTIERREZ, ORLANDO M, POLLOCK, DAVID M · 2019 to 2023
$3.3M
Per1 and the kidney clock in hypertensionR01DK109570 · NIDDK · UNIVERSITY OF FLORIDA · PI GUMZ, MICHELLE L · 2017 to 2021
$1.5M
Nocturnal Hypertension and SleepK23HL141682 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ABDALLA, MARWAH · 2019 to 2023
$953k
Modulation of the renal aldosterone endothelin feedback system by the clock protein PER1R56DK128271 · NIDDK · UNIVERSITY OF FLORIDA · PI GUMZ, MICHELLE L, WINGO, CHARLES S · 2021 to 2021
$100k
NHLBI NIH HHS K23 HL141682NHLBI NIH HHS R01 HL142648NHLBI NIH HHS R01 HL144716NHLBI NIH HHS R35 HL155670NIDDK NIH HHS R01 DK109570NIDDK NIH HHS R56 DK128271
6 · The paper itself

Abstract

Healthy individuals exhibit blood pressure variation over a 24-hour period with higher blood pressure during wakefulness and lower blood pressure during sleep. Loss or disruption of the blood pressure circadian rhythm has been linked to adverse health outcomes, for example, cardiovascular disease, dementia, and chronic kidney disease. However, the current diagnostic and therapeutic approaches lack sufficient attention to the circadian rhythmicity of blood pressure. Sleep patterns, hormone release, eating habits, digestion, body temperature, renal and cardiovascular function, and other important host functions as well as gut microbiota exhibit circadian rhythms, and influence circadian rhythms of blood pressure. Potential benefits of nonpharmacologic interventions such as meal timing, and pharmacologic chronotherapeutic interventions, such as the bedtime administration of antihypertensive medications, have recently been suggested in some studies. However, the mechanisms underlying circadian rhythm-mediated blood pressure regulation and the efficacy of chronotherapy in hypertension remain unclear. This review summarizes the results of the National Heart, Lung, and Blood Institute workshop convened on October 27 to 29, 2021 to assess knowledge gaps and research opportunities in the study of circadian rhythm of blood pressure and chronotherapy for hypertension.

Indexed as

HypertensionNational Heart, Lung, and Blood Institute (U.S.)Antihypertensive AgentsBlood PressureChronotherapyCircadian RhythmHumansPrecision MedicineUnited StatesAntihypertensive Agentscircadian clockkidneymicrobiotasleepvasculature

Identifiers

PMID36448463
PMCPMC9931676

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.