ArticleGeneral psychiatry2022
Investigating genetic causal relationships between blood pressure and anxiety, depressive symptoms, neuroticism and subjective well-being.
Article in General psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Association of depressive and anxiety symptoms with blood pressure in first-episode, treatment-naïve patients with depression: a cross-sectional study.Scientific reports · 2026Article
- Prevalence of depression and anxiety and related influencing factors in the Chinese population with noncommunicable chronic diseases: A network perspective.World journal of psychiatry · 2025Article
- Predicting hypertension through big five personality traits: a four-year longitudinal study in Japan.BMC psychology · 2025Article
- Anxiety and hypertensive disorders of pregnancy: Epidemiology, mechanisms, and management strategies.World journal of psychiatry · 2025Review
- Aggression and Justice Involvement: Does Uric Acid Play a Role?Brain sciences · 2025Article
- Association between the subclinical level of problematic internet use and habenula volume: a look at mediation effect of neuroticism.General psychiatry · 2025Article
- Exploring the Causal Relationships and Mediating Factors Between Mental Disorders and Hypertension: A Multivariable Mendelian Randomization Study.Global heart · 2025Article
- Predictors of Psychological Well-Being and Quality of Life in Patients with Hypertension: A Longitudinal Study.Healthcare (Basel, Switzerland) · 2024Article
- Triple digital divide and depressive symptoms among middle-aged and older Chinese adults: a disparity analysis.General psychiatry · 2024Article
- Behavioural approach-avoidance tendencies among individuals with elevated blood pressure.Current psychology (New Brunswick, N.J.) · 2023Article
- Shared genetics and bidirectional causal relationships between type 2 diabetes and attention-deficit/hyperactivity disorder.General psychiatry · 2023Article
- Why caution should be applied when interpreting and promoting findings from Mendelian randomisation studies.General psychiatry · 2023Article
- Mental stress, atheroma, myocardial ischaemia and injury: the link is inflammation.General psychiatry · 2023Review
- Causal associations between major depressive disorder and COVID-19.General psychiatry · 2023Article
- Special issue for psychosomatic medicine.General psychiatry · 2022Article
Corrections and comments
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Authors and funding
3 authors.
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Abstract
Background: High blood pressure is a leading cardiovascular disease risk factor and considered to be associated with psychological factors. However, the causal relationships between blood pressure and anxiety, depressive symptoms, neuroticism and subjective well-being are not clear. Aims: The current study explored the genetic causal relationships between blood pressure and anxiety, depressive symptoms, neuroticism and subjective well-being. Methods: Mendelian randomisation (MR) analyses were performed using the generalised summary-data-based MR analysis method with eight large-scale genome-wide association study datasets for hypertension, systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure, anxiety, depressive symptoms, neuroticism and subjective well-being. Results: A causal effect of DBP on neuroticism was found, and 1074 independent instrumental single nucleotide polymorphisms were identified by the incorporated Heterogeneity in Dependent Instruments-outlier test among the bidirectional causal relationship between blood pressure and the four psychological states. Conclusions: DBP has a causal effect on neuroticism. Appropriate management of blood pressure may reduce neuroticism, neuroticism-inducing mood disorders and cardiovascular diseases.
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