Evidence map›Paper›PMID 36447740›Full record

ArticleJournal of Alzheimer's disease reports2022

Vascular Brain Lesions, Cognitive Reserve, and Their Association with Cognitive Profile in Persons with Early-Stage Cognitive Decline.

Romella Durrani, Amanpreet Badhwar, Jaspreet Bhangu, Aravind Ganesh, Sandra E Black, Philip A Barber, Richard Frayne, Thalia S Field, Vladimir Hachinski, Demetrios Sahlas and 4 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Cognitive reserve against vascular contributions to cognitive impairment and dementia: A scoping review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Romella DurraniDepartment of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Amanpreet BadhwarDepartment of Pharmacology and Physiology, University of Montreal, and Centre de recherche de l'Institut Universitaire de de Gériatrie, Université de Montreal, Montreal, QC, Canada.
Jaspreet BhanguDepartment of Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Aravind GaneshDepartment of Clinical Neurosciences and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Sandra E BlackDepartment of Medicine (Neurology), Hurvitz Brain Sciences Program, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
Philip A BarberDepartment of Clinical Neurosciences and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Richard FrayneSeaman Family MR Research Centre, Foothills Medical Centre and Department of Radiology and Clinical Neurosciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Thalia S FieldDepartment of Medicine (Neurology), Djavad Mowafaghian Centre for Brain Health, Vancouver Stroke Program, University of British Columbia, Vancouver, BC, Canada.
Vladimir HachinskiDepartment of Clinical Neurological Sciences, Western University, London, ON, Canada.
Demetrios SahlasDepartment of Medicine (Neurology), Population Health Research Institute, McMaster University, Hamilton, ON, Canada.
Lauren M MaiDepartment of Clinical Neurological Sciences, Western University, London, ON, Canada.
Mukul SharmaDepartment of Medicine (Neurology), Population Health Research Institute, McMaster University, Hamilton, ON, Canada.
Richard H SwartzDepartment of Medicine (Neurology), Hurvitz Brain Sciences Program, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
Eric E SmithDepartment of Clinical Neurosciences and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
University of Calgary · CAWestern University · CAPopulation Health Research Institute · CASunnybrook Health Science Centre · CAInstitut Universitaire de Gériatrie de Montréal · CAUniversity of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cognitive reserve may protect against the effects of brain pathology, but few studies have looked at whether cognitive reserve modifies the adverse effects of vascular brain pathology. Objective: We determined if cognitive reserve attenuates the associations of vascular brain lesions with worse cognition in persons with subjective concerns or mild impairment. Methods: We analyzed 200 participants aged 50-90 years from the Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS-ND) study. Cognition was measured using the Montreal Cognitive Assessment and a neuropsychological test battery. High vascular lesion burden was defined as two or more supratentorial infarcts or beginning confluent or confluent white matter hyperintensity. Cognitive reserve proxies included education, occupational attainment, marital status, social activities, physical activity, household income, and multilingualism. Results: Mean age was 72.8 years and 48% were female; 73.5% had mild cognitive impairment and 26.5% had subjective concerns. Professional/managerial occupations, annual household income≥$60,000 per year, not being married/common law, and high physical activity were independently associated with higher cognition. Higher vascular lesion burden was associated with lower executive function, but the association was not modified by cognitive reserve. Conclusion: Markers of cognitive reserve are associated with higher cognition. Vascular lesion burden is associated with lower executive function. However, cognitive reserve does not mitigate the effects of vascular lesion burden on executive function. Public health efforts should focus on preventing vascular brain injury as well as promoting lifestyle factors related to cognitive reserve, as cognitive reserve alone may not mitigate the effects of vascular brain injury.

Indexed as

Brain vascular disorderscerebral small vessel diseasecerebrovascular diseasecognitive dysfunctioncognitive reserveinfarctwhite matter disease

Identifiers

PMID36447740
PMCPMC9661348
OpenAlexW4296077679

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.