Evidence map›Paper›PMID 36447624›Full record

ArticleJournal of vascular and interventional neurology2022

Superior cervical ganglion stimulation results in potent cerebral vasoconstriction in swine.

Wi Jin Kim, Hasitha Milan Samarage, David Zarrin, Keshav Goel, Christopher Chan, Xin Qi, Anthony Wang, Kalyanam Shivkumar, Jeffrey Ardell, Geoffrey P Colby

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of vascular and interventional neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Wi Jin KimDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, California, USA.
Hasitha Milan SamarageDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, California, USA.
David ZarrinDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Keshav GoelDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Christopher ChanCardiac Arrhythmia Center, Department of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Xin QiDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Anthony WangDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, California, USA.
Kalyanam ShivkumarCardiac Arrhythmia Center, Department of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Jeffrey ArdellCardiac Arrhythmia Center, Department of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Geoffrey P ColbyDepartment of Neurosurgery, University of California Los Angeles, Los Angeles, California, USA.
University of California, Los Angeles · US

Funding

UCLA Neurosurgery Research Training and Education ProgramR25NS079198 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LIAU, LINDA M · 2012 to 2021
$1.2M
NINDS NIH HHS R25 NS079198
6 · The paper itself

Abstract

Introduction: Sympathetic activity from the superior cervical ganglion (SCG) has been shown to cause cerebral hypoperfusion in swine, similar to that seen with clinical cerebral vasospasm. Although the mechanism of such perfusion deficit has been speculated to be from pathologic cerebral vasoconstriction, the extent of sympathetic contribution to vasoconstriction has not been wellestablished. Objective: We aimed to demonstrate that SCG stimulation in swine leads to significant cerebral vasoconstriction on digital subtraction angiography (DSA). Additionally, we aimed to show that inhibition of SCG can mitigate the effects of sympathetic-mediated cerebral vasoconstriction. Methods: Five SCGs were surgically identified in Yorkshire swine and were electrically stimulated to achieve sympathetic activation. DSA was performed to measure and compare changes in cerebral vessel diameter. Syngo iFlow was also used to quantify changes in contrast flow through the cerebral and neck vessels. Results: SCG stimulation resulted in 35-45% narrowing of the ipsilateral ascending pharyngeal, anterior middle cerebral and anterior cerebral arteries. SCG stimulation also decreased contrast flow through ipsilateral ascending pharyngeal, internal carotid and anterior cerebral arteries as seen on iFLow. These effects were prevented with prior SCG blockade. Minimal vessel caliber changes were seen in the posterior cerebral, posterior middle cerebral and internal carotid arteries with SCG stimulation. Conclusion: SCG stimulation results in significant luminal narrowing and reduction in flow through various intracranial arteries in swine. The results of sympathetic hyperactivity from the SCG closely models cerebral vasoconstriction seen in human cerebral vasospasm. SCG inhibition is a potential promising therapeutic approach to treating cerebral vasospasm.

Identifiers

PMID36447624
PMCPMC9703949
OpenAlexW4310700289

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.