Evidence map›Paper›PMID 36447434›Full record

ReviewClinical endocrinology2023

The effect of hormone replacement therapy on cognition and mood.

Aditi Sharma, Rhianna Davies, Aditi Kapoor, Heraa Islam, Lisa Webber, Channa N Jayasena

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Aditi SharmaDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID 0000-0002-3198-0879
Rhianna DaviesDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Aditi KapoorManipal Medical School, Manipal, India.
Heraa IslamManipal Medical School, Manipal, India.
Lisa WebberDepartment of Gynaecology, St. Mary's Hospital, London, UK.
Channa N JayasenaDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID 0000-0002-2578-8223
Imperial College London · GBManipal Academy of Higher Education · INSt. Mary's Hospital · GB

Funding

NIHR Imperial Biomedical Research Centre (BRC) Funding Scheme BBSRCNIHR Imperial Biomedical Research Centre (BRC) Funding Scheme MRC
6 · The paper itself

Abstract

objectivesTo summarise the available data regarding the effect of hormone replacement therapy (HRT) on cognition and mood in women.

backgroundComplaints of impaired cognition and mood are common in the peri-menopausal and menopausal period. There is debate as to whether HRT can ameliorate this phenomenon.

designA literature search of studies using electronic databases was conducted. Both randomised control trials and observational studies were included. PATIENTS: Perimenopausal and menopausal women.

resultsDue to the heterogenicity of results it is challenging to draw firm conclusions. The preparations used in many of the studies are older regimes no longer routinely used clinically. The notion of a 'critical window' for HRT is compelling, suggesting HRT has a positive impact on cognition when administered in the peri-menopausal or early postmenopausal period but may have negative effects on cognition in the older, postmenopausal woman. The evidence would seem to suggest importance of hormonal replacement in woman undergoing a surgical menopause, especially when young. It remains unclear for how long they ought to continue HRT though until at least the natural age of the menopause seems reasonable. Evidence for a positive effect of HRT on mood is more convincing, though possibly more efficacious in the younger age group. The effect of HRT on anxiety is less clear.

conclusionsFurther study, particularly focusing on the more contemporaneous HRT preparations, is warranted before evidence-based conclusions can be drawn.

Indexed as

Estrogen Replacement TherapyHormone Replacement TherapyCognitionFemaleHumansMenopausePostmenopausecognitionhormone replacement therapymenopausemoodoestrogen therapywomen

Identifiers

PMID36447434
PMCPMC11497347
OpenAlexW4310461019

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.