ArticleCritical care (London, England)2022
One-year hospital readmission for recurrent sepsis: associated risk factors and impact on 1-year mortality-a French nationwide study.
Article in Critical care (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- The American Society for Microbiology's evidence-based laboratory medicine practice guidelines for the diagnosis of bloodstream infections using rapid tests: a systematic review and meta-analysis.Clinical microbiology reviews · 2025Guideline
- Post-Sepsis Outcomes: Risk Factors for 90-Day Mortality and Infection Site-Pathogen Similarity in Recurrent Sepsis.Turkish journal of anaesthesiology and reanimation · 2026Article
- Trajectories of sepsis survivors in Australia: A scoping review.Journal of the Intensive Care Society · 2026Article
- Article
- Patterns and predictors of readmission among sepsis survivors in a tertiary emergency department in Ethiopia.IJID regions · 2026Article
- Risk Factors for Adverse Outcomes in Cancer Patients With Sepsis.Journal of clinical medicine research · 2026Article
- Nonlinear association between stress hyperglycemia ratio and short-term and long-term mortality in sepsis patients with atrial fibrillation: a cohort study.Frontiers in endocrinology · 2026Article
- Endothelial cells retain inflammatory memory through chromatin remodeling in a two-hit model of infection-induced inflammation.American journal of physiology. Cell physiology · 2025Article
- Causality of genetically predicted solid cancers on risk of sepsis: insights from Mendelian randomization.Discover oncology · 2025Article
- SHRs, biomarkers for dysregulated stress response, predict prognosis in sepsis patients: a retrospective cohort study from MIMIC-IV database.BMC infectious diseases · 2025Article
- Association of stress hyperglycemia ratio and mortality in patients with sepsis: results from 13,199 patients.Infection · 2024Article
- Post-discharge functional outcomes in older patients with sepsis.Critical care (London, England) · 2024Article
- Prognostic impacts of repeated sepsis in intensive care unit on autoimmune disease patients: a retrospective cohort study.BMC infectious diseases · 2024Article
- Sepsis in Latvia-Incidence, Outcomes, and Healthcare Utilization: A Retrospective, Observational Study.Healthcare (Basel, Switzerland) · 2024Article
- Article
- Care pathways of sepsis survivors: sequelae, mortality and use of healthcare services in France, 2015-2018.Critical care (London, England) · 2023Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSepsis is a complex health condition, leading to long-term morbidity and mortality. Understanding the risk factors for recurrent sepsis, as well as its impact on mid- and long-term mortality among other risk factors, is essential to improve patient survival.
methodsA risk factor analysis, based on French nationwide medico-administrative data, was conducted on a cohort of patients above 15 years old, hospitalized with an incident sepsis in metropolitan France between 1st January 2018 and 31st December 2018 and who survived their index hospitalization. Two main analyses, focusing on outcomes occurring 1-year post-discharge, were conducted: a first one to assess risk factors for recurrent sepsis and a second to assess risk factors for mortality.
resultsOf the 178017 patients surviving an incident sepsis episode in 2018 and included in this study, 22.3% died during the 1-year period from discharge and 73.8% had at least one hospital readmission in acute care, among which 18.1% were associated with recurrent sepsis. Patients aged between 56 and 75, patients with cancer and renal disease, with a long index hospital stay or with mediastinal or cardiac infection had the highest odds of recurrent sepsis. One-year mortality was higher for patients with hospital readmission for recurrent sepsis (aOR 2.93; 99% CI 2.78-3.09). Among all comorbidities, patients with cancer (aOR 4.35; 99% CI 4.19-4.52) and dementia (aOR 2.02; 99% CI 1.90-2.15) had the highest odds of 1-year mortality.
conclusionHospital readmission for recurrent sepsis is one of the most important risk factors for 1-year mortality of septic patients, along with age and comorbidities. Our study suggests that recurrent sepsis, as well as modifiable or non-modifiable other risk factors identified, should be considered in order to improve patient care pathway and survival.
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