Evidence map›Paper›PMID 36447234›Full record

ArticleMalaria journal2022

Gene Coverage Count and Classification (GC

Thomas C Stabler, Ankit Dwivedi, Biraj Shrestha, Sudhaunshu Joshi, Tobias Schindler, Amed Ouattara, Guillermo A García, Claudia Daubenberger, Joana C Silva

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Malaria journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Thomas C StablerDepartment of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland. thomas.stabler@swisstph.ch.
Ankit DwivediInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Biraj ShresthaMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Sudhaunshu JoshiMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Tobias SchindlerDepartment of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.
Amed OuattaraMalaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Guillermo A GarcíaMedical Care Development International, Silver Spring, MD, USA.
Claudia DaubenbergerDepartment of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.
Joana C SilvaInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA. jcsilva@som.umaryland.edu.
University of Maryland, Baltimore · USSwiss Tropical and Public Health Institute · CHMedical Care Development International · USUniversity of Basel · CH

Funding

Technology CoreU19AI110820 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI WHITE, OWEN R · 2014 to 2023
$36.5M
Designing a diversity-covering multiantigen multi-strain vaccineK01HL140285 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI OUATTARA, AMED · 2019 to 2023
$712k
NHLBI NIH HHS 1K01HL140285-01A1NHLBI NIH HHS K01 HL140285NIAID NIH HHS U19 AI110820NIH HHS U19 AI110820
6 · The paper itself

Abstract

backgroundThe ability of malaria rapid diagnostic tests (RDTs) to effectively detect active infections is being compromised by the presence of malaria strains with genomic deletions at the hrp2 and hrp3 loci, encoding the antigens most commonly targeted in diagnostics for Plasmodium falciparum detection. The presence of such deletions can be determined in publically available P. falciparum whole genome sequencing (WGS) datasets. A computational approach was developed and validated, termed Gene Coverage Count and Classification (GC

methodsGC

resultsGC

conclusionsThe GC

Indexed as

HistidineTool Use BehaviorGenotypePlasmodium falciparumWhole Genome SequencingHistidineBioinformaticsDeletionGene coverageGenomicshrp2hrp3MalariaRapid Diagnostic Test

Identifiers

PMID36447234
PMCPMC9706933
OpenAlexW4310207328

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.