Evidence map›Paper›PMID 36447181›Full record

ArticleBMC public health2022

The relationship between HIV pre-exposure prophylaxis, sexually transmitted infections, and antimicrobial resistance: a qualitative interview study of men who have sex with men.

Adam Dale Newman Williams, Fiona Wood, David Gillespie, Zoë Couzens, Kathryn Hughes, Kerenza Hood

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in BMC public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07370948 (Study of the Antibiotic-resistance Profile of Enterobacterales Isolated From Rectal Mucosal Buffer of PrEP Subjects), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07370948 recruitingnot on this mapstarted 2025, after this paper: background citation

Study of the Antibiotic-resistance Profile of Enterobacterales Isolated From Rectal Mucosal Buffer of PrEP Subjects

TypeobservationalSponsorIRCCS Azienda Ospedaliero-Universitaria di BolognaRan2025 to 2026Enrolled200ConditionsInfection
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. HIV Pre-Exposure Prophylaxis (PrEP) Users' Experiences of PrEP Access, Sexual Behaviour, and Well-Being During the COVID-19 Pandemic: A Welsh Qualitative Study.Health expectations : an international journal of public participation in health care and health policy · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Adam Dale Newman WilliamsCentre for Trials Research, School of Medicine, College of Biomedical & Life Sciences, Cardiff University, Wales, UK. WilliamsAD7@cardiff.ac.uk.
Fiona WoodDivision of Population Medicine, School of Medicine, College of Biomedical & Life Sciences, Cardiff University, Wales, UK.
David GillespieCentre for Trials Research, School of Medicine, College of Biomedical & Life Sciences, Cardiff University, Wales, UK.
Zoë CouzensPublic Health Wales NHS Trust, Wales, UK.
Kathryn HughesDivision of Population Medicine, School of Medicine, College of Biomedical & Life Sciences, Cardiff University, Wales, UK.
Kerenza HoodCentre for Trials Research, School of Medicine, College of Biomedical & Life Sciences, Cardiff University, Wales, UK.
Cardiff University · GBPublic Health Wales · GBUniversity of Wales · GB

Funding

HCRW_ HF-17-1411
6 · The paper itself

Abstract

backgroundHIV pre-exposure prophylaxis (PrEP) is a medication that prevents the acquisition of HIV. It has been targeted towards men who have sex with men (MSM). Since its introduction there have been concerns raised around changes in sexual behaviour such as increased condomless anal intercourse (CAI), leading to an elevation in sexually transmitted infections (STIs). With antimicrobial resistant strains of STIs rising, there are concerns that PrEP may be contributing to this growth. This study aims to understand how MSM conceptualise the relationship between PrEP, STIs and antimicrobial resistance (AMR).

methodsTwenty semi-structured interviews were conducted online using Zoom. Participants include a mix of PrEP related experiences (never used, currently use, previously used). Reflexive thematic analysis was undertaken by the lead author with 10% of transcripts double coded.

resultsMSM in Wales have positive views and a good knowledge of PrEP and awareness of bacterial STIs. PrEP is perceived by many to lead to a reduction in condom use and increase in STIs but reported condom use behaviours presented to be stable in terms of PrEP initiation. PrEP use is influenced by increased concern for HIV and minimal concern for bacterial STIs. Awareness of AMR STIs was lacking.

conclusionsThere is a belief that PrEP use will lead to an increase in STI rates through reduced condom use, despite reported behaviours often being stable in relation to PrEP initiation, PrEP stigma may be influencing this dichotomy. Concern and awareness for resistant STIs is low, with little association to PrEP.

Indexed as

HIV InfectionsPre-Exposure ProphylaxisSexual and Gender MinoritiesSexually Transmitted DiseasesAnti-Bacterial AgentsDrug Resistance, BacterialHomosexuality, MaleHumansMaleQualitative ResearchSexual BehaviorAnti-Bacterial AgentsAntimicrobial resistanceHIVPre-exposure prophylaxisQualitative researchSexual and gender minoritiesSexual behaviourSexually transmitted infections

Identifiers

PMID36447181
PMCPMC9708133
OpenAlexW4310474444

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.