Evidence map›Paper›PMID 36447175›Full record

ArticleBMC cancer2022

Patient reported outcomes based on EQ-5D-5L questionnaires in head and neck cancer patients: a real-world study.

Tanja Sprave, Eleni Gkika, Vivek Verma, Anca-Ligia Grosu, Raluca Stoian

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06086990 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Effects in Quality of Life of a Telemonitoring Platform Amongst Patients With Cancer: A Randomized Trial

TypeinterventionalSponsorUniversidad Nacional Andres BelloRan2024 to 2025Enrolled80ConditionsCancer, Telemonitoring, Telemedicine, Symptoms and SignsArmsContigo Application
NCT06711731 recruitingnot on this mapstarted 2024, after this paper: background citation

The Freiburg Registry on SpontanEous IntercrAnial Hypotension (SIH) & Post-duraL Puncture Headache (PDPH)

Typeobservational_patient_registrySponsorUniversity Hospital FreiburgRan2024 to 2036Enrolled2,000ConditionsCerebroSpinal Fluid (CSF) Leak
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Tanja SpraveDepartment of Radiation Oncology, Freiburg University Medical Center, Robert-Koch-Str. 3, 79106, Freiburg, Germany. tanja.sprave@uniklinik-freiburg.de.
Eleni GkikaDepartment of Radiation Oncology, Freiburg University Medical Center, Robert-Koch-Str. 3, 79106, Freiburg, Germany.
Vivek VermaDepartment of Radiation Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Anca-Ligia GrosuDepartment of Radiation Oncology, Freiburg University Medical Center, Robert-Koch-Str. 3, 79106, Freiburg, Germany.
Raluca StoianDepartment of Radiation Oncology, Freiburg University Medical Center, Robert-Koch-Str. 3, 79106, Freiburg, Germany.
German Cancer Research Center · DEUniversity Medical Center Freiburg · DEThe University of Texas MD Anderson Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveHealth economic comparisons of various therapies are often based on health-related quality of life (HRQOL) using EQ-5D questionnaires within the framework of clinical trials. This real-world study prospectively evaluates the patient reported outcomes (PROs)-based HRQOL of head-and-neck (H&N) cancer patients undergoing modern radiotherapy (RT) to reflect PRO trajectories.

methodsAll H&N cancer patients treated in our clinic between July 2019 and December 2020 who completed the self-reported validated EQ-5D-5L questionnaire (health state index (HI) and Visual Analog Scale (VAS)) at baseline, end of radiotherapy, and at each respective follow up (FU) were included. Descriptive analysis of clinical and sociodemographic data, the frequency and level of each dimension was conducted. To assess the significance of therapy-induced HRQOL changes within and between the group, a distribution-based approach was used.

resultsAltogether, 366 participants completed a total of 565 questionnaires. For the whole cohort, HI at baseline was 0.804 (±0.208), 0.830 (±0.162) at RT completion, 0.812 (±0.205) at the first follow-up, and 0.769 (±0.224) at the second follow-up. The respective VAS values were 62.06 (±23,94), 66.73 (±82.20), 63.30 (±22.74), and 65.48 (±23.39). Females showed significantly lower HI values compared to males, but only at baseline (p = 0.034). Significantly lower HI values were also seen in patients with definitive RT as compared to adjuvant RT at baseline (p = 0.023), the second follow-up (p = 0.047), and the third follow-up (p = 0.010). As compared to outpatients, inpatients had significantly lower HI values at RT completion (p = 0.017), the second follow-up (p = 0.007), and the third follow-up (p = 0.031). Subgroup analyses by age (< 65 vs. ≥65) and smoking status (smokers vs. non-smokers) showed no difference at any time point.

conclusionPROs demonstrated detectability of time- and intra-/inter-group therapy-induced HRQOL changes. A further detailed exploration of EQ-5D-5L responsiveness for H&N cancer patients is required.

Indexed as

Head and Neck NeoplasmsQuality of LifeFemaleHumansMalePatient Reported Outcome MeasuresSelf ReportVisual Analog ScaleEQ-5D-5LHead-and-neck cancerPatient reported outcomeRadiotherapy

Identifiers

PMID36447175
PMCPMC9710161
OpenAlexW4310484240

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.