Evidence map›Paper›PMID 36447142›Full record

Trial reportBMC pregnancy and childbirth2022

Granulocyte colony stimulating factor versus human chorionic gonadotropin for recurrent implantation failure in intra cytoplasmic sperm injection: a randomized clinical trial.

Mohamed Sobhy Bakry, Elsayed Eldesouky, Moatazza Mahdy Alghazaly, Elsayed Farag, Eslam Elsayed Kamal Sultan, Hossam Elazzazy, Attia Mohamed, Soliman Mohamed Said Ali, Assem Anwar, Asmaa Ahmed Elrashedy and 3 more

RetractedOpen access · goldAbstract readComparative StudyRandomized Controlled TrialRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC pregnancy and childbirth, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Observational
  5. Review
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Mohamed Sobhy BakryDepartment of Obstetrics and Gynecology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Elsayed EldesoukyDepartment of Obstetrics and Gynecology, Faculty of Medicine, Alazhar University, Cairo, Egypt.
Moatazza Mahdy AlghazalyDepartment of Obstetrics and Gynecology, Faculty of Medicine Girls, Alazhar University, Cairo, Egypt.
Elsayed FaragDepartment of Obstetrics and Gynecology, Faculty of Medicine, Alazhar University, Cairo, Egypt.
Eslam Elsayed Kamal SultanDepartment of Obstetrics and Gynecology, Faculty of Medicine, Alazhar University, Cairo, Egypt.
Hossam ElazzazyDepartment of Obstetrics and Gynecology, Faculty of Medicine, Alazhar University, Cairo, Egypt.
Attia MohamedDepartment of Obstetrics and Gynecology, Faculty of Medicine, Alazhar University, Cairo, Egypt.
Soliman Mohamed Said AliDepartment of Obstetrics and Gynecology, Faculty of Medicine, Alazhar University, Domiata, Egypt.
Assem AnwarDepartment of Obstetrics and Gynecology, Faculty of Medicine, Alazhar University, Cairo, Egypt.
Asmaa Ahmed ElrashedyFaculty of Medicine, Kafr El-Shaikh University, Kafr El-Shaikh, Egypt.
Mohamed AbdelmonemFaculty of Medicine, Fayoum University, Fayoum, Egypt. ma3701@fayoum.edu.eg.
Mohamed Abd-ElGawadFaculty of Medicine, Fayoum University, Fayoum, Egypt.
Almandouh H BosilahDepartment of Obstetrics and Gynecology, Faculty of Medicine, Domiata University, Domiata, Egypt.
Al-Azhar University · EGFayoum University · EGKafrelsheikh University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRepeated implantation failure (RIF) is defined as the case whereby the transferred embryos fail to implant after several attempts of In vitro fertilization (IVF) which causes a profound impact on the quality of life and financial burden. Some clinical studies have confirmed that Granulocyte colony-stimulating factor (G-CSF) and human chorionic gonadotropin (HCG) can improve pregnancy outcomes and implantation rates. Hence, our study aims to compare the efficacy of G-CSF and HCG on pregnancy outcomes in RIF women who undergo intra-cytoplasmic sperm injection (ICSI).

methodsThis randomized, single-blinded study was conducted et al.-Azhar University Hospitals, Cairo, Egypt, between 10

resultsIn 100 RIF women, we found a significant improvement in pregnancy outcomes favoring G-CSF over HCG including implantation rate, chemical pregnancy, and clinical pregnancy (P < 0.0001, P = 0.0003, and P = 0.0006, respectively).

conclusionFor the first time, we demonstrated a significant improvement in pregnancy outcomes favoring G-CSF over HCG in terms of implantation rate, chemical pregnancy, and clinical pregnancy.

trial registrationThe study was registered on Pan African Clinical Trials Registry with the following number: PACTR202010482774275 and was approved on 2

Indexed as

Chorionic GonadotropinEmbryo ImplantationGranulocyte Colony-Stimulating FactorSperm Injections, IntracytoplasmicAbortion, SpontaneousAdultEmbryo TransferFemaleFertilization in VitroHumansInjections, IntramuscularMalePregnancyPregnancy OutcomeQuality of LifeSemenChorionic GonadotropinGranulocyte Colony-Stimulating FactorG-CSFHCGICSIIVFRIF

Identifiers

PMID36447142
PMCPMC9706918
OpenAlexW4310191635

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.