Evidence map›Paper›PMID 36446868›Full record

ArticleScientific reports2022

Fasting increases susceptibility to acute myocardial ischaemia/reperfusion injury through a sirtuin-3 mediated increase in fatty acid oxidation.

Andrew R Hall, Qutuba G Karwi, Sanjeev Kumar, Rachel Dongworth, Dunja Aksentijević, Tariq R Altamimi, Kevin Timothy Fridianto, Kroekkiat Chinda, Sauri Hernandez-Resendiz, Mohammad U Mahmood and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 9 institutions in 6 countries.

Andrew R Hall *The Hatter Cardiovascular Institute, University College London, London, UK.
Qutuba G Karwi *Cardiovascular Research Centre, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, AB, T6G 2S2, Canada.
Sanjeev KumarBoard of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Rachel DongworthThe Hatter Cardiovascular Institute, University College London, London, UK.
Dunja AksentijevićWilliam Harvey Research Institute, Centre for Biochemical Pharmacology, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK.
Tariq R AltamimiCardiovascular Research Centre, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, AB, T6G 2S2, Canada.
Kevin Timothy FridiantoCardiovascular & Metabolic Disorders Program, Duke-National University of Singapore Medical School, 8 College Road, Singapore, 169857, Singapore.
Kroekkiat ChindaDepartment of Physiology, Faculty of Medical Science, Naresuan University, Phitsanulok, Thailand.
Sauri Hernandez-ResendizNational Heart Research Institute Singapore, National Heart Centre, Singapore, Singapore.
Mohammad U MahmoodCardiovascular Research Centre, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, AB, T6G 2S2, Canada.
Evangelos MichelakisSchool of Cardiovascular Medicine and Sciences, British Heart Foundation Centre of Research Excellence, King's College London, The Rayne Institute, St Thomas' Hospital, London, UK.
Chrishan J RamachandraCardiovascular & Metabolic Disorders Program, Duke-National University of Singapore Medical School, 8 College Road, Singapore, 169857, Singapore.
Jianhong ChingCardiovascular & Metabolic Disorders Program, Duke-National University of Singapore Medical School, 8 College Road, Singapore, 169857, Singapore.
Jose M VicencioThe Hatter Cardiovascular Institute, University College London, London, UK.
Michael J ShattockSchool of Cardiovascular Medicine and Sciences, British Heart Foundation Centre of Research Excellence, King's College London, The Rayne Institute, St Thomas' Hospital, London, UK.
Jean-Paul KovalikCardiovascular & Metabolic Disorders Program, Duke-National University of Singapore Medical School, 8 College Road, Singapore, 169857, Singapore.
Derek M YellonThe Hatter Cardiovascular Institute, University College London, London, UK.
Gary LopaschukCardiovascular Research Centre, University of Alberta, 423 Heritage Medical Research Centre, Edmonton, AB, T6G 2S2, Canada.
Derek J HausenloyThe Hatter Cardiovascular Institute, University College London, London, UK. derek.hausenloy@duke-nus.edu.sg.
National University of Singapore · SGUniversity College London · GBUniversity of Alberta · CACedars-Sinai Medical Center · USKing's College London · GBNaresuan University · THNational Heart Centre Singapore · SGQueen Mary University of London · GBSt Thomas' Hospital · GB

Funding

British Heart Foundation FS/10/039/28270British Heart Foundation RG/17/15/33106Medical Research Council MR/J003530/1Wellcome Trust
6 · The paper itself

Abstract

Fasting increases susceptibility to acute myocardial ischaemia/reperfusion injury (IRI) but the mechanisms are unknown. Here, we investigate the role of the mitochondrial NAD

Indexed as

Myocardial Reperfusion InjurySirtuin 3AnimalsFastingFatty AcidsGlucoseMiceMice, KnockoutFatty AcidsGlucoseSirt3 protein, mouseSirtuin 3

Identifiers

PMID36446868
PMCPMC9708654
OpenAlexW4310240453

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.