ArticleNPJ genomic medicine2022
Brain single cell transcriptomic profiles in episodic memory phenotypes associated with temporal lobe epilepsy.
Article in NPJ genomic medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- Deciphering epileptogenic and activity-dependent gene programs in the human brain.bioRxiv : the preprint server for biology · 2026Article
- Proteomic Studies in Absence Epilepsy: A Systematic Review of Methodological Diversity and Implications for Data Interpretation.Current issues in molecular biology · 2026Review
- Dentate gyrus is needed for memory retrieval.Molecular psychiatry · 2024Article
- Application of spatial transcriptome technologies to neurological diseases.Frontiers in cell and developmental biology · 2023Review
- Single-cell transcriptomics: A new tool for studying diabetic kidney disease.Frontiers in physiology · 2022Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Memory dysfunction is prevalent in temporal lobe epilepsy (TLE), but little is known about the underlying molecular etiologies. Single-nucleus RNA sequencing technology was used to examine differences in cellular heterogeneity among left (language-dominant) temporal neocortical tissues from patients with TLE with (n = 4) or without (n = 2) impairment in verbal episodic memory. We observed marked cell heterogeneity between memory phenotypes and identified numerous differentially expressed genes across all brain cell types. The most notable differences were observed in glutamatergic (excitatory) and GABAergic (inhibitory) neurons with an overrepresentation of genes associated with long-term potentiation, long-term depression, and MAPK signaling, processes known to be essential for episodic memory formation.
Identifiers
What OpenQuestion holds
Registered trials
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