Evidence map›Paper›PMID 36446785›Full record

ArticleNature communications2022

Structures of the R-type human Ca

Xia Yao, Yan Wang, Zhifei Wang, Xiao Fan, Di Wu, Jian Huang, Alexander Mueller, Sarah Gao, Miaohui Hu, Carol V Robinson and 3 more

Abstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Characterization of Three Distinct Loss-of-Function Cav2.3 Variants.International journal of molecular sciences · 2026
    Article
  2. Review
  3. Voltage-sensing domains: structural and functional diversity.European biophysics journal : EBJ · 2025
    Review
  4. Article
  5. Article
  6. Calcium channels as pharmacological targets for cancer therapy.Clinical and experimental medicine · 2025
    Review
  7. Review
  8. Voltage sensors.Molecular pharmacology · 2025
    Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. MODY Only Monogenic? A Narrative Review of theInternational journal of molecular sciences · 2024
    Review
  15. Pathology of pain and its implications for therapeutic interventions.Signal transduction and targeted therapy · 2024
    Review
  16. Article
  17. Structural basis for human CaCell research · 2024
    Article
  18. The Dysfunction of CaInternational journal of molecular sciences · 2023
    Review
  19. Article
  20. Cryo-EM structure of human voltage-gated sodium channel NaProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xia YaoDepartment of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA.ORCID 0000-0003-2406-268X
Yan WangDepartment of Biological Sciences, St. John's University, Queens, NY, 11439, USA.
Zhifei WangDepartment of Biological Sciences, St. John's University, Queens, NY, 11439, USA.ORCID 0000-0002-5494-6745
Xiao FanDepartment of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA.
Di WuPhysical and Theoretical Chemistry Laboratory, University of Oxford, Oxford, OX1 3QZ, UK.ORCID 0000-0001-9748-4408
Jian HuangDepartment of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA.
Alexander MuellerDepartment of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA.ORCID 0000-0002-7447-1310
Sarah GaoDepartment of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA.ORCID 0000-0002-1157-3942
Miaohui HuDepartment of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA.
Carol V RobinsonPhysical and Theoretical Chemistry Laboratory, University of Oxford, Oxford, OX1 3QZ, UK.ORCID 0000-0001-7829-5505
Yong YuDepartment of Biological Sciences, St. John's University, Queens, NY, 11439, USA.ORCID 0000-0002-1849-0779
Shuai GaoDepartment of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA. gaoshuai812@whu.edu.cn.ORCID 0000-0002-8734-2489
Nieng YanDepartment of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA. nyan@princeton.edu.ORCID 0000-0003-4829-7416

Funding

Molecular mechanisms of action and resistance of sodium channel-targeting insectiR01GM057440 · NIGMS · MICHIGAN STATE UNIVERSITY · PI DONG, KE, HUGHSON, FREDERICK M · 1999 to 2023
$5.4M
Ion Channel Function and Regulation of the Polycystin-1/2 Complex in Kidney Physiology and Polycystic Kidney DiseaseR01DK125404 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI QIAN, FENG, YU, YONG · 2020 to 2024
$2.7M
Structural investigation of the gating and regulatory mechanism of voltage-gated Ca2+ channelsR01GM130762 · NIGMS · PRINCETON UNIVERSITY · PI YAN, NIENG · 2019 to 2022
$1.4M
NIDDK NIH HHS R01 DK125404NIGMS NIH HHS R01 GM057440NIGMS NIH HHS R01 GM130762Wellcome TrustWellcome Trust 221795/Z/20/Z
6 · The paper itself

Abstract

The R-type voltage-gated Ca

Indexed as

Cell Physiological PhenomenaSeizuresCross ReactionsCytosolHumansMolecular Conformation

Identifiers

PMID36446785
PMCPMC9708679

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.