Evidence map›Paper›PMID 36446760›Full record

ArticleNature communications2022

A population-based serological study of post-COVID syndrome prevalence and risk factors in children and adolescents.

Roxane Dumont, Viviane Richard, Elsa Lorthe, Andrea Loizeau, Francesco Pennacchio, María-Eugenia Zaballa, Hélène Baysson, Mayssam Nehme, Anne Perrin, Arnaud G L'Huillier and 6 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
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  9. Altered COVID-19 immunity in children with asthma by atopic status.The journal of allergy and clinical immunology. Global · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Roxane DumontUnit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland.ORCID 0000-0001-5910-9025
Viviane RichardUnit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland.ORCID 0000-0003-2697-5191
Elsa LortheUnit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland.ORCID 0000-0002-9654-8104
Andrea LoizeauUnit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland.
Francesco PennacchioUnit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland.ORCID 0000-0003-4967-7242
María-Eugenia ZaballaUnit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland.ORCID 0000-0002-0613-9519
Hélène BayssonUnit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland.
Mayssam NehmeDepartment of Health and Community Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.ORCID 0000-0001-9189-6495
Anne PerrinDivision of General Pediatrics, Department of Woman, Child, and Adolescent Medicine, Geneva University Hospitals, Geneva, Switzerland.ORCID 0000-0002-2023-3157
Arnaud G L'HuillierDivision of General Pediatrics, Department of Woman, Child, and Adolescent Medicine, Geneva University Hospitals, Geneva, Switzerland.
Laurent KaiserGeneva Center for Emerging Viral Diseases and Laboratory Virology, Geneva University Hospitals, Geneva, Switzerland.ORCID 0000-0002-0857-2252
Rémy P BarbeDivision of Child and Adolescent Psychiatry, Department of Woman, Child, and Adolescent Medicine, Geneva University Hospitals, Geneva, Switzerland.ORCID 0000-0002-1851-1787
Klara M Posfay-BarbeDivision of General Pediatrics, Department of Woman, Child, and Adolescent Medicine, Geneva University Hospitals, Geneva, Switzerland.ORCID 0000-0001-9464-5704
Silvia Stringhini *Unit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland.ORCID 0000-0002-4387-8943
SEROCoV-KIDS study group
Idris Guessous *Department of Health and Community Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland. Idris.Guessous@hcuge.ch.ORCID 0000-0002-0491-6089
University Hospital of Geneva · CHUniversity of Geneva · CHJohns Hopkins University · USWorld Health Organization · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Post-COVID syndrome remains poorly studied in children and adolescents. Here, we aimed to investigate the prevalence and risk factors of pediatric post-COVID in a population-based sample, stratifying by serological status. Children from the SEROCoV-KIDS cohort study (State of Geneva, Switzerland), aged 6 months to 17 years, were tested for anti-SARS-CoV-2 N antibodies (December 2021-February 2022) and parents filled in a questionnaire on persistent symptoms in their children (lasting over 12 weeks) compatible with post-COVID. Of 1034 children tested, 570 (55.1%) were seropositive. The sex- and age-adjusted prevalence of persistent symptoms among seropositive children was 9.1% (95%CI: 6.7;11.8) and 5.0% (95%CI: 3.0;7.1) among seronegatives, with an adjusted prevalence difference (ΔaPrev) of 4.1% (95%CI: 1.1;7.3). Stratifying per age group, only adolescents displayed a substantial risk of having post-COVID symptoms (ΔaPrev = 8.3%, 95%CI: 3.5;13.5). Identified risk factors for post-COVID syndrome were older age, having a lower socioeconomic status and suffering from chronic health conditions, especially asthma. Our findings show that a significant proportion of seropositive children, particularly adolescents, experienced persistent COVID symptoms. While there is a need for further investigations, growing evidence of pediatric post-COVID urges early screening and primary care management.

Indexed as

COVID-19AdolescentAntibodies, ViralChildCohort StudiesHumansPrevalenceRisk FactorsSyndromeAntibodies, Viral

Identifiers

PMID36446760
PMCPMC9708639
OpenAlexW4310289044

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.