Evidence map›Paper›PMID 36446523›Full record

ArticleLife science alliance2023

The mechanosensitive ion channel PIEZO1 promotes satellite cell function in muscle regeneration.

Kotaro Hirano, Masaki Tsuchiya, Akifumi Shiomi, Seiji Takabayashi, Miki Suzuki, Yudai Ishikawa, Yuya Kawano, Yutaka Takabayashi, Kaori Nishikawa, Kohjiro Nagao and 8 more

Open access · goldAbstract read
In one paragraph

Article in Life science alliance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. PIEZO1 Mediates Myoblast Proliferation Under Simulated Microgravity.Annals of the New York Academy of Sciences · 2026
    Article
  3. Review
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  14. Article
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  16. Open biology · 2025
    Review
  17. Review
  18. Article
  19. MgScience advances · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 1 country.

Kotaro HiranoDepartment of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan.
Masaki TsuchiyaDepartment of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan.ORCID 0000-0001-8191-3183
Akifumi ShiomiMicrofluidics RIKEN Hakubi Research Team, RIKEN Cluster for Pioneering Research, Wako, Saitama, Japan.
Seiji TakabayashiDepartment of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan.
Miki SuzukiSchool of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
Yudai IshikawaSchool of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
Yuya KawanoSchool of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
Yutaka TakabayashiSchool of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
Kaori NishikawaMicrofluidics RIKEN Hakubi Research Team, RIKEN Cluster for Pioneering Research, Wako, Saitama, Japan.
Kohjiro NagaoDepartment of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan.
Eiji UmemotoSchool of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
Yasuo KitajimaDepartment of Immunology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.ORCID 0000-0001-6277-5918
Yusuke OnoDepartment of Muscle Development and Regeneration, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan.ORCID 0000-0002-4802-7507
Keiko NonomuraDivision of Embryology, National Institute for Basic Biology, Aichi, Japan.
Hirofumi ShintakuMicrofluidics RIKEN Hakubi Research Team, RIKEN Cluster for Pioneering Research, Wako, Saitama, Japan.ORCID 0000-0002-9972-4222
Yasuo MoriDepartment of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan.
Masato UmedaDepartment of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan.
Yuji HaraSchool of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan yhara@u-shizuoka-ken.ac.jp.ORCID 0000-0003-0021-1740
University of Shizuoka · JPKyoto University · JPPioneer (Japan) · JPHiroshima University · JPKumamoto University · JPTokyo Institute of Technology · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Muscle satellite cells (MuSCs), myogenic stem cells in skeletal muscles, play an essential role in muscle regeneration. After skeletal muscle injury, quiescent MuSCs are activated to enter the cell cycle and proliferate, thereby initiating regeneration; however, the mechanisms that ensure successful MuSC division, including chromosome segregation, remain unclear. Here, we show that PIEZO1, a calcium ion (Ca

Indexed as

Ion ChannelsRegenerationSatellite Cells, Skeletal MuscleAnimalsChromosome SegregationMiceMuscle, SkeletalMyoblastsSignal TransductionIon ChannelsPiezo1 protein, mouse

Identifiers

PMID36446523
PMCPMC9711862
OpenAlexW4310286702

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.