Evidence map›Paper›PMID 36445970›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Natural and synthetic inhibitors of a phage-encoded quorum-sensing receptor affect phage-host dynamics in mixed bacterial communities.

Justin E Silpe, Olivia P Duddy, Bonnie L Bassler

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Revisiting the life cycle of temperate phages.Nature reviews. Microbiology · 2026
    Review
  2. Prophage-Derived Molecules as Anti-Antibiotics (Basel, Switzerland) · 2026
    Review
  3. Article
  4. mBio · 2026
    Article
  5. Exploring phage-host interactions inMicrobiology spectrum · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Justin E SilpeDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544.
Olivia P DuddyDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544.
Bonnie L BasslerDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544.ORCID 0000-0002-0043-746X
Howard Hughes Medical Institute · USPrinceton University · US

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007388 · NIGMS · PRINCETON UNIVERSITY · PI CRISTEA, ILEANA M. · 1985 to 2022
$27.4M
Intra- and Inter- Species Communication in BacteriaR37GM065859 · NIGMS · PRINCETON UNIVERSITY · PI BASSLER, BONNIE L · 2016 to 2025
$3.4M
Howard Hughes Medical InstituteNIGMS NIH HHS R37 GM065859NIGMS NIH HHS T32 GM007388
6 · The paper itself

Abstract

Viruses that infect bacteria, called phages, shape the composition of bacterial communities and are important drivers of bacterial evolution. We recently showed that temperate phages, when residing in bacteria (i.e., prophages), are capable of manipulating the bacterial cell-to-cell communication process called quorum sensing (QS). QS relies on the production, release, and population-wide detection of signaling molecules called autoinducers (AI). Gram-negative bacteria commonly employ

Indexed as

AeromonasBacteriophagesBacteriophage ReceptorsProphagesQuorum SensingTrans-ActivatorsBacteriophage ReceptorsTrans-ActivatorsLuxRphagequorum sensing

Identifiers

PMID36445970
PMCPMC9894119
OpenAlexW4310565249

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.