ArticleProgress in biomaterials2023
Albumin-loaded thermo/pH dual-responsive nanogels based on sodium alginate and poly (N-vinyl caprolactam).
Article in Progress in biomaterials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 9 citations in OpenAlex.
- Bovine Colostrum-Derived Lactoferrin Nanoparticles as a Novel Platform for Improved Pulmonary Delivery of Osimertinib.Cell biochemistry and biophysics · 2026Article
- Effects of Melatonin-Loaded Poly(N-vinylcaprolactam) Transdermal Gel on Sleep Quality.Gels (Basel, Switzerland) · 2025Article
- Sustainable and Surfactant-Free Synthesis of Negatively Charged Acrylamide Nanogels for Biomedical Applications.Macromolecules · 2025Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the past decades, many researchers have tried to encapsulate medicines in biopolymer nanogels as injectable medicines. In the present study, dual-responsive bovine serum albumin (BSA)-loaded nanogels prepared from sodium alginate grafted poly (N-vinyl caprolactam) (PNVCL) have been reported. First, PNVCL-g-sodium alginate (PNVCL-g-Alg) was synthesized through free radical polymerization, and then nanogels were obtained from ionic crosslinking of sodium alginate in the presence of BSA. FTIR spectra showed that PNVCL-g-Alg nanogels were successfully prepared. Turbidimetry and rheometry analyses demonstrated the cloud point temperature near the human body. Particle size was evaluated using FE-SEM and dynamic light scattering and it was found that the size of particles in dry and swollen state are about 30 and 280 nm, respectively. The effect of temperature and pH on BSA release was evaluated. By comparing the drug release behavior, we found that the release of the protein at the temperature above the cloud point is faster than that at the temperature below the cloud point. The pH sensitivity of BSA-loaded PNVCL-g-Alg was evaluated at pH 5.5 and 7.4 and showed that the drug release was faster at acidic pH than at neutral pH.
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