Evidence map›Paper›PMID 36445664›Full record

ArticleThe international journal of cardiovascular imaging2022

Arrhythmogenic cardiomyopathy and differential diagnosis with physiological right ventricular remodelling in athletes using cardiovascular magnetic resonance.

Eleonora Moccia, Efstathios Papatheodorou, Chris J Miles, Ahmed Merghani, Aneil Malhotra, Harshil Dhutia, Rachel Bastiaenen, Nabeel Sheikh, Abbas Zaidi, Giuseppe Damiano Sanna and 9 more

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Article in The international journal of cardiovascular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 2 countries.

Eleonora MocciaCardiology Clinical Academic Group, St George's University of London and St George's University Hospital NHS Foundation Trust, London, UK. e.moccia@studenti.uniss.it.ORCID http://orcid.org/0000-0002-1999-1049
Efstathios PapatheodorouCardiology Clinical Academic Group, St George's University of London and St George's University Hospital NHS Foundation Trust, London, UK.
Chris J MilesCardiology Clinical Academic Group, St George's University of London and St George's University Hospital NHS Foundation Trust, London, UK.
Ahmed MerghaniCardiology Clinical Academic Group, St George's University of London and St George's University Hospital NHS Foundation Trust, London, UK.
Aneil MalhotraCardiology Clinical Academic Group, St George's University of London and St George's University Hospital NHS Foundation Trust, London, UK.
Harshil DhutiaCardiology Clinical Academic Group, St George's University of London and St George's University Hospital NHS Foundation Trust, London, UK.
Rachel BastiaenenCardiology Clinical Academic Group, St George's University of London and St George's University Hospital NHS Foundation Trust, London, UK.
Nabeel SheikhCardiology Clinical Academic Group, St George's University of London and St George's University Hospital NHS Foundation Trust, London, UK.
Abbas ZaidiCardiology Clinical Academic Group, St George's University of London and St George's University Hospital NHS Foundation Trust, London, UK.
Giuseppe Damiano SannaClinical and Interventional Cardiology, Sassari University Hospital, Via Enrico de Nicola 1, Sassari, Italy.
Tessa HomfrayCardiology Clinical Academic Group, St George's University of London and St George's University Hospital NHS Foundation Trust, London, UK.
Nicholas BunceCardiology Clinical Academic Group, St George's University of London and St George's University Hospital NHS Foundation Trust, London, UK.
Lisa J AndersonCardiology Clinical Academic Group, St George's University of London and St George's University Hospital NHS Foundation Trust, London, UK.
Maite TomeCardiology Clinical Academic Group, St George's University of London and St George's University Hospital NHS Foundation Trust, London, UK.
Elijah BehrCardiology Clinical Academic Group, St George's University of London and St George's University Hospital NHS Foundation Trust, London, UK.
James MoonBarts Heart Centre, St Bartholomew's Hospital, London, UK.
Sanjay SharmaCardiology Clinical Academic Group, St George's University of London and St George's University Hospital NHS Foundation Trust, London, UK.
Gherardo Finocchiaro *Cardiology Clinical Academic Group, St George's University of London and St George's University Hospital NHS Foundation Trust, London, UK.
Michael Papadakis *Cardiology Clinical Academic Group, St George's University of London and St George's University Hospital NHS Foundation Trust, London, UK.
St George's, University of London · GBSt Thomas' Hospital · GBUniversity of Sassari · ITSt Bartholomew's Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To describe the overlap between structural abnormalities typical of arrhythmogenic right ventricular cardiomyopathy (ARVC) and physiological right ventricular adaptation to exercise and differentiate between pathologic and physiologic findings using CMR. We compared CMR studies of 43 patients (mean age 49 ± 17 years, 49% males, 32 genotyped) with a definitive diagnosis of ARVC with 97 (mean age 45 ± 16 years, 61% males) healthy athletes. CMR was abnormal in 37 (86%) patients with ARVC, but only 23 (53%) fulfilled a major or minor CMR criterion according to the TFC. 7/20 patients who did not fulfil any CMR TFC showed pathological finding (RV RWMA and fibrosis in the LV or LV RWMA). RV was affected in isolation in 17 (39%) patients and 18 (42%) patients showed biventricular involvement. Common RV abnormalities included RWMA (n = 34; 79%), RV dilatation (n = 18; 42%), RV systolic dysfunction (≤ 45%) (n = 17; 40%) and RV LGE (n = 13; 30%). The predominant LV abnormality was LGE (n = 20; 47%). 22/32 (69%) patients exhibited a pathogenic variant: PKP2 (n = 17, 53%), DSP (n = 4, 13%) and DSC2 (n = 1, 3%). Sixteen (16%) athletes exceeded TFC cut-off values for RV volumes. None of the athletes exceeded a RV/LV end-diastolic volume ratio > 1.2, nor fulfilled TFC for impaired RV ejection fraction. The majority (86%) of ARVC patients demonstrate CMR abnormalities suggestive of cardiomyopathy but only 53% fulfil at least one of the CMR TFC. LV involvement is found in 50% cases. In athletes, an RV/LV end-diastolic volume ratio > 1.2 and impaired RV function (RVEF ≤ 45%) are strong predictors of pathology.

Indexed as

Arrhythmogenic Right Ventricular DysplasiaVentricular RemodelingAdultAgedAthletesDiagnosis, DifferentialFemaleHumansMagnetic Resonance SpectroscopyMaleMiddle AgedPredictive Value of TestsArrhythmogenic cardiomyopathyAthlete’s heartCardiac magnetic resonance

Identifiers

PMID36445664
OpenAlexW4286383001

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.