Evidence map›Paper›PMID 36445654›Full record

ArticleDigestive diseases and sciences2023

Prognostic Benefit of Additional Treatment After Endoscopic Submucosal Dissection for Esophageal Squamous Cell Carcinoma.

So Takahashi, Waku Hatta, Kenta Watanabe, Tomoyuki Koike, Tomohiro Shimada, Takuto Hikichi, Yosuke Toya, Ippei Tanaka, Yusuke Onozato, Koichi Hamada and 22 more

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Article in Digestive diseases and sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 18 institutions in 1 country.

So TakahashiDepartment of Gastroenterology, Akita University Graduate School of Medicine, Akita, Japan.
Waku HattaDivision of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan. waku-style@festa.ocn.ne.jp.ORCID http://orcid.org/0000-0001-9717-0281
Kenta WatanabeDepartment of Gastroenterology, Akita University Graduate School of Medicine, Akita, Japan.
Tomoyuki KoikeDivision of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.
Tomohiro ShimadaDepartment of Gastroenterology, Sendai City Medical Center, Sendai, Miyagi, Japan.
Takuto HikichiDepartment of Endoscopy, Fukushima Medical University Hospital, Fukushima, Japan.
Yosuke ToyaDivision of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Yahaba, Iwate, Japan.
Ippei TanakaDepartment of Gastroenterology, Sendai Kousei Hospital, Sendai, Miyagi, Japan.
Yusuke OnozatoDepartment of Gastroenterology, Faculty of Medicine, Yamagata University, Yamagata, Japan.
Koichi HamadaDepartment of Minimally Invasive Surgical and Medical Oncology, Fukushima Medical University, Fukushima, Japan.
Daisuke FukushiDivision of Gastroenterology, Tohoku Medical and Pharmaceutical University School of Medicine, Sendai, Miyagi, Japan.
Ko WatanabeDepartment of Gastroenterology, Ohara General Hospital, Fukushima, Japan.
Shoichi KayabaDepartment of Gastroenterology, Iwate Prefectural Isawa Hospital, Ohshu, Iwate, Japan.
Hirotaka ItoDepartment of Gastroenterology, Osaki Citizen Hospital, Osaki, Miyagi, Japan.
Tatsuya MikamiDivision of Endoscopy, Hirosaki University Hospital, Hirosaki, Aomori, Japan.
Tomoyuki OikawaDepartment of Gastroenterology, Miyagi Cancer Center, Natori, Miyagi, Japan.
Yasushi TakahashiDepartment of Gastroenterology, National Hospital Organization Sendai Medical Center, Sendai, Miyagi, Japan.
Yutaka KondoDepartment of Gastroenterology, Tohoku Rosai Hospital, Sendai, Miyagi, Japan.
Tetsuro YoshimuraDepartment of Gastroenterology, Aomori City Hospital, Aomori, Japan.
Takeharu ShirokiDepartment of Gastroenterology, Iwate Prefectural Central Hospital, Morioka, Iwate, Japan.
Ko NaginoDepartment of Gastroenterology, Yamagata Prefectural Central Hospital, Yamagata, Japan.
Norihiro HanabataDivision of Endoscopy, Aomori Prefectural Central Hospital, Aomori, Japan.
Akira FunakuboDepartment of Gastroenterology, Fukushima Medical University Aizu Medical Center, Fukushima, Japan.
Dai HirasawaDepartment of Gastroenterology, Sendai Kousei Hospital, Sendai, Miyagi, Japan.
Tetsuya OhiraDepartment of Gastroenterology, Sendai City Medical Center, Sendai, Miyagi, Japan.
Jun NakamuraDepartment of Endoscopy, Fukushima Medical University Hospital, Fukushima, Japan.
Tomohiro NakamuraDepartment of Health Record Informatics, Tohoku Medical Megabank Organization, Tohoku University, Miyagi, Japan.
Naoki NakayaDepartment of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Miyagi, Japan.
Takayuki MatsumotoDivision of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Yahaba, Iwate, Japan.
Shinsaku FukudaNational University Corporation Hirosaki University, Hirosaki, Aomori, Japan.
Atsushi MasamuneDivision of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.
Katsunori IijimaDepartment of Gastroenterology, Akita University Graduate School of Medicine, Akita, Japan.
Tohoku University · JPAkita University · JPSendai Medical Center · JPFukushima Medical University · JPFukushima Medical University Hospital · JPIwate Medical University · JPIwate Prefectural Central Hospital · JPSendai Kousei Hospital · JPAomori Prefectural Central Hospital · JPAomori Rosai Hospital · JPHirosaki University · JPHirosaki University Hospital · JPMiyagi Prefectural Hospital Organization · JPOsaki Citizen Hospital · JPTohoku Medical and Pharmaceutical University · JPTohoku Rosai Hospital · JPYamagata Prefectural Central Hospital · JPYamagata University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough additional treatment is considered for patients with esophageal squamous cell carcinoma (ESCC) invading into the muscularis mucosa (pT1a-MM) or submucosa (pT1b-SM) after endoscopic submucosal dissection (ESD), the actual benefits of this method remain to be elucidated.

aimsWe aimed to evaluate the prognostic benefits of additional treatment in such patients.

methodsBetween 2006 and 2017, we enrolled patients with pT1a-MM/pT1b-SM ESCC after ESD at 21 institutions in Japan. Overall survival (OS) and disease-specific survival (DSS) were compared between the additional treatment and follow-up groups after propensity score matching, to reduce the bias of baseline characteristics. A subgroup analysis was performed according to the pathological findings: category A, pT1a-MM but negative for lymphovascular invasion (LVI) and vertical margin (VM); category B, tumor invasion into the submucosa ≤ 200 μm but negative for LVI and VM; category C, others.

resultsOf 593 patients with pT1a-MM/pT1b-SM ESCC after ESD, 101 matched pairs were extracted after propensity score matching. The OSs were similar between the additional treatment and follow-up groups (80.6% vs. 78.6% in 5 years; P = 0.972). In a subgroup analysis, the OS in the additional treatment group was significantly lower than that in the follow-up group (65.7% vs. 95.2% in 5 years; P = 0.037) in category A, whereas OS did not significantly differ in category C (76.8% vs. 69.5% in 5 years; P = 0.360).

conclusionsAdditional treatment after ESD in patients with pT1a-MM/pT1b-SM ESCC was not associated with an improved prognosis.

Indexed as

Endoscopic Mucosal ResectionEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaHumansPrognosisRetrospective StudiesTreatment OutcomeAdditional treatmentEndoscopic submucosal dissectionEsophageal squamous cell carcinomaPrognosis

Identifiers

PMID36445654
OpenAlexW4310239187

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.