Evidence map›Paper›PMID 36445517›Full record

ArticleJournal of autism and developmental disorders2024

Severity of Autism Spectrum Disorder Symptoms Associated with de novo Variants and Pregnancy-Induced Hypertension.

Xiaomeng Wang, Zhengbao Ling, Tengfei Luo, Qiao Zhou, Guihu Zhao, Bin Li, Kun Xia, Jinchen Li

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of autism and developmental disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Impact of interaction between individual genomes and preeclampsia on the severity of autism spectrum disorder symptoms.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Xiaomeng Wang *Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, 41008, Hunan, China.
Zhengbao Ling *Centre for Medical Genetics, Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, 41008, Hunan, China.
Tengfei LuoCentre for Medical Genetics, Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, 41008, Hunan, China.
Qiao ZhouDepartment of Geriatrics, Xiangya Hospital, Central South University, Changsha, 41008, Hunan, China.
Guihu ZhaoDepartment of Geriatrics, Xiangya Hospital, Central South University, Changsha, 41008, Hunan, China.
Bin LiDepartment of Geriatrics, Xiangya Hospital, Central South University, Changsha, 41008, Hunan, China.
Kun XiaCentre for Medical Genetics, Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, 41008, Hunan, China. xiakun@sklmg.edu.cn.
Jinchen LiDepartment of Geriatrics, Xiangya Hospital, Central South University, Changsha, 41008, Hunan, China. lijinchen@csu.edu.cn.ORCID http://orcid.org/0000-0003-3335-9303
Central South University · CN

Funding

Hunan Natural Science Foundation Outstanding Youth Fund 2020JJ3059Hunan Youth Science and Technology Innovation Talent Project 2020RC3060National Major Science and Technology Projects of China 2018SK1030National Natural Science Foundation of China 81730036National Natural Science Foundation of China 81801133
6 · The paper itself

Abstract

Genetic factors, particularly, de novo variants (DNV), and an environment factor, exposure to pregnancy-induced hypertension (PIH), were reported to be associated with risk of autism spectrum disorder (ASD); however, how they jointly affect the severity of ASD symptom is unclear. We assessed the severity of core ASD symptoms affected by functional de novo variants or PIH. We selected phenotype data from Simon's Simplex Collection database, used genotypes from previous studies, and created linear regression models. We found that ASD patients carrying DNV with PIH exposure had increased adaptive and cognitive ability, decreased social problems, and enhanced repetitive behaviors; however, there was no difference in patients without DNV between those with or without PIH exposure. In addition, the DNV genes carried by patients exposed to PIH were enriched in ubiquitin-dependent proteolytic processes, highlighting how candidate genes in pathways and environments interact. The results indicate the joint contribution of DNV and PIH to ASD.

Indexed as

Autism Spectrum DisorderHypertension, Pregnancy-InducedCognitionFemaleGenotypeHumansPhenotypePregnancyAutism spectrum disorderDe novo variantGene ontologyPregnancy-induced hypertensionSymptomsUbiquitin-dependent protein catabolic process

Identifiers

PMID36445517
OpenAlexW4310207250

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.