Evidence map›Paper›PMID 36445458›Full record

ArticleEuropean journal of clinical pharmacology2023

Prevalence trends and individual patterns of ADHD medication use in pregnancy in Norway and Sweden, 2010-2019.

Jacqueline M Cohen, Chaitra Srinivas, Kari Furu, Carolyn E Cesta, Johan Reutfors, Øystein Karlstad

Open access · hybridAbstract read
In one paragraph

Article in European journal of clinical pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Jacqueline M CohenDepartment of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway. jacqueline.cohen@fhi.no.ORCID http://orcid.org/0000-0002-7300-0488
Chaitra SrinivasDepartment of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway.ORCID http://orcid.org/0000-0002-5928-2108
Kari FuruDepartment of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway.ORCID http://orcid.org/0000-0003-2245-0179
Carolyn E CestaCentre for Pharmacoepidemiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-5759-9366
Johan ReutforsCentre for Pharmacoepidemiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-1372-4262
Øystein KarlstadDepartment of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway.ORCID http://orcid.org/0000-0003-1204-787X
Norwegian Institute of Public Health · NOKarolinska Institutet · SE

Funding

ADHD Research Network of the Norwegian Centre of Expertise for Neurodevelopmental Disorders and Hypersomnias #51379Norges Forskningsråd 273366Norges Forskningsråd 301977
6 · The paper itself

Abstract

purposeThis study aimed to describe recent trends in ADHD medication use in pregnancy in Norway and Sweden, including prevalence, individual characteristics, and patterns of use.

methodsWe studied ADHD medication use (amphetamine, dexamphetamine, methylphenidate, atomoxetine, lisdexamfetamine, guanfacine) by year and age in pregnancies from 2010 to 2019 identified from the medical birth registers (gestational age ≥ 22 weeks) linked to prescribed drug registers (Norway, N = 577,116; Sweden, N = 1,118,988). We compared characteristics of those who used any ADHD medication in pregnancy to no use in pregnancy. Discontinuation was defined as no use after first trimester.

resultsADHD medication use increased from 2010 to 2019 by 3.0 users per 1000 pregnancies in Norway (from 2.5 to 5.5/1000) and by 6.3 per 1000 in Sweden (from 1.6 to 7.9/1000), mainly driven by methylphenidate and since 2015 by lisdexamfetamine. Medication use has increased among pregnant individuals of all age groups, with higher use among the youngest. Pregnant individuals who used ADHD medication were less likely to be married/cohabiting, more likely be nulliparous and to smoke. They had particularly high use of co-medication with antidepressants, anxiolytics/hypnotics, and opioids: 42% in Norway and 65% in Sweden used at least one additional class of psychotropic medication. Most individuals discontinued ADHD medication in pregnancy (85% Norway, 78% Sweden).

conclusionADHD medication use during pregnancy increased in Norway and Sweden in the last decade. However, discontinuation rates during pregnancy were high. Those who used ADHD medication had more risk factors for pregnancy complications including low parity, smoking, and other psychotropic drug use.

Indexed as

Attention Deficit Disorder with HyperactivityCentral Nervous System StimulantsMethylphenidateAtomoxetine HydrochlorideFemaleHumansLisdexamfetamine DimesylateNorwayPregnancyPrevalenceSwedenAtomoxetine HydrochlorideCentral Nervous System StimulantsLisdexamfetamine DimesylateMethylphenidateAttention deficit-hyperactivity disorderCentral nervous system stimulantsDrug utilization studyNordic health registersPregnancy

Identifiers

PMID36445458
PMCPMC9816174
OpenAlexW4310220260

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.