Evidence map›Paper›PMID 36445204›Full record

ArticleJournal of the American Chemical Society2022

Role of Serine Coordination in the Structural and Functional Protection of the Nitrogenase P-Cluster.

Hannah L Rutledge, Mackenzie J Field, Jonathan Rittle, Michael T Green, F Akif Tezcan

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. What Can be Learned From the Electrostatic Environments Within Nitrogenase Enzymes?Chemistry (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  3. Article
  4. NifEN: a versatile player in nitrogenase assembly, catalysis and evolution.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025
    Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Hannah L RutledgeDepartment of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0340, United States.ORCID 0000-0002-8672-2797
Mackenzie J FieldDepartment of Chemistry, University of California, Irvine, Irvine, California 92697, United States.
Jonathan RittleDepartment of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0340, United States.ORCID 0000-0001-6241-6253
Michael T GreenDepartment of Chemistry, University of California, Irvine, Irvine, California 92697, United States.ORCID 0000-0001-8658-8420
F Akif TezcanDepartment of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0340, United States.ORCID 0000-0002-4733-6500
University of California San Diego · USUniversity of California, Irvine · US

Funding

MOLECULAR BIOPHYSICS TRAINING PROGRAMT32GM008326 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KOMIVES, ELIZABETH A. · 1989 to 2020
$7.5M
Thermodynamic, Electronic, Structural, and Kinetic Characterizations of Cytochrome P450 Compounds I & IIR01GM101390 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI MICHAEL T. GREEN · 2012 to 2026
$3.0M
Mechanism of Energy Transduction and Substrate Activation in Biological Nitrogen FixationR01GM148607 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI F. Akif Tezcan · 2023 to 2026
$1.3M
Mechanism of Energy Transduction and Substrate Activation in Biological NitrogenR01GM099813 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TEZCAN, FAIK AKIF · 2012 to 2016
$1.3M
Preparation of Artificial Dicopper Enzymes for the Catalytic Reduction of CO2F32GM120981 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RITTLE, JONATHAN D · 2016 to 2017
$102k
NIGMS NIH HHS F32 GM120981NIGMS NIH HHS R01 GM099813NIGMS NIH HHS R01 GM101390NIGMS NIH HHS R01 GM148607NIGMS NIH HHS T32 GM008326
6 · The paper itself

Abstract

Nitrogenase catalyzes the multielectron reduction of dinitrogen to ammonia. Electron transfer in the catalytic protein (MoFeP) proceeds through a unique [8Fe-7S] cluster (P-cluster) to the active site (FeMoco). In the reduced, all-ferrous (P

Indexed as

NitrogenaseSerineLigandsLigandsNitrogenaseSerine

Identifiers

PMID36445204
PMCPMC9957664
OpenAlexW4310361315

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.