Evidence map›Paper›PMID 36445153›Full record

ArticleMicrobiology spectrum2022

Characteristics of the GlnH and GlnX Signal Transduction Proteins Controlling PknG-Mediated Phosphorylation of OdhI and 2-Oxoglutarate Dehydrogenase Activity in Corynebacterium glutamicum.

Lea Sundermeyer, Graziella Bosco, Srushti Gujar, Melanie Brocker, Meike Baumgart, Dieter Willbold, Oliver H Weiergräber, Marco Bellinzoni, Michael Bott

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lea Sundermeyer *IBG-1: Biotechnology, Institute of Bio- and Geosciences, Forschungszentrum Jülichgrid.8385.6, Jülich, Germany.
Graziella Bosco *IBG-1: Biotechnology, Institute of Bio- and Geosciences, Forschungszentrum Jülichgrid.8385.6, Jülich, Germany.
Srushti GujarIBG-1: Biotechnology, Institute of Bio- and Geosciences, Forschungszentrum Jülichgrid.8385.6, Jülich, Germany.
Melanie BrockerIBG-1: Biotechnology, Institute of Bio- and Geosciences, Forschungszentrum Jülichgrid.8385.6, Jülich, Germany.
Meike BaumgartIBG-1: Biotechnology, Institute of Bio- and Geosciences, Forschungszentrum Jülichgrid.8385.6, Jülich, Germany.ORCID 0000-0002-9874-1151
Dieter WillboldIBI-7: Structural Biochemistry, Institute of Biological Information Processing, Forschungszentrum Jülichgrid.8385.6, Jülich, Germany.ORCID 0000-0002-0065-7366
Oliver H WeiergräberIBI-7: Structural Biochemistry, Institute of Biological Information Processing, Forschungszentrum Jülichgrid.8385.6, Jülich, Germany.
Marco BellinzoniInstitut Pasteur, Université de Paris Cité, CNRS UMR3528, Unité de Microbiologie Structurale, Paris, France.ORCID 0000-0002-8887-6917
Michael BottIBG-1: Biotechnology, Institute of Bio- and Geosciences, Forschungszentrum Jülichgrid.8385.6, Jülich, Germany.ORCID 0000-0002-4701-8254

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In Corynebacterium glutamicum the protein kinase PknG phosphorylates OdhI and thereby abolishes the inhibition of 2-oxoglutarate dehydrogenase activity by unphosphorylated OdhI. Our previous studies suggested that PknG activity is controlled by the periplasmic binding protein GlnH and the transmembrane protein GlnX, because Δ

Indexed as

Corynebacterium glutamicumMycobacterium tuberculosisPeriplasmic Binding ProteinsAspartic AcidBacterial ProteinsGlutamic AcidGlutamineKetoglutarate Dehydrogenase ComplexKetoglutaric AcidsPhosphorylationProtein KinasesSignal TransductionAspartic AcidBacterial ProteinsGlutamic AcidGlutamineKetoglutarate Dehydrogenase ComplexKetoglutaric AcidsPeriplasmic Binding ProteinsProtein Kinases2-oxoglutarate dehydrogenaseActinobacteriabacterial signalingCorynebacterium glutamicumforkhead-associated domainfour-helix bundleperiplasmic binding proteinprotein phosphorylationserine/threonine kinasessignal transduction

Identifiers

PMID36445153
PMCPMC9769921

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.