Evidence map›Paper›PMID 36445090›Full record

ArticleJournal of clinical microbiology2022

Sensitivity of Detection and Variant Typing of SARS-CoV-2 in European Laboratories.

Ramona Mögling, Carlo Fischer, Kamelia R Stanoeva, Angeliki Melidou, Angélica C Almeida Campos, Christian Drosten, Barbara Biere, Adam Meijer, Annette Kraus, Chantal B E M Reusken and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. SARS-CoV-2 EncephalitisCurrent pediatric reviews · 2024
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Ramona Mögling *Centre for Infectious Disease Control, National Institute for Public Health and the Environmentgrid.31147.30 (RIVM), Bilthoven, the Netherlands.ORCID 0000-0002-3990-8329
Carlo Fischer *Institute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humbolt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0001-9163-2406
Kamelia R Stanoeva *Centre for Infectious Disease Control, National Institute for Public Health and the Environmentgrid.31147.30 (RIVM), Bilthoven, the Netherlands.ORCID 0000-0002-9518-5102
Angeliki MelidouEuropean Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden.
Angélica C Almeida CamposInstitute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humbolt-Universität zu Berlin, Berlin, Germany.
Christian DrostenInstitute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humbolt-Universität zu Berlin, Berlin, Germany.
Barbara BiereRobert Koch Institute (RKI)grid.13652.33, Berlin, Germany.
Adam MeijerCentre for Infectious Disease Control, National Institute for Public Health and the Environmentgrid.31147.30 (RIVM), Bilthoven, the Netherlands.
Annette KrausEuropean Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden.
Chantal B E M ReuskenCentre for Infectious Disease Control, National Institute for Public Health and the Environmentgrid.31147.30 (RIVM), Bilthoven, the Netherlands.
Jan Felix DrexlerInstitute of Virology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humbolt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0002-3509-0232
Humboldt-Universität zu Berlin · DENational Institute for Public Health and the Environment · NLEuropean Centre for Disease Prevention and Control · SERobert Koch Institute · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The molecular detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is key for clinical management and surveillance. Funded by the European Centre for Disease Prevention and Control, we conducted an external quality assessment (EQA) on the molecular detection and variant typing of SARS-CoV-2 that included 59 European laboratories in 34 countries. The EQA panel consisted of 12 lyophilized inactivated samples, 10 of which were SARS-CoV-2 variants (Alpha, Beta, Gamma, Delta, Epsilon, Eta, parental B.1 strain) ranging from 2.5 to 290.0 copies/μL or pooled respiratory viruses (adenovirus, enterovirus, influenza virus A, respiratory syncytial virus, or human coronaviruses 229E and OC43). Of all participants, 72.9% identified the presence of SARS-CoV-2 RNA correctly. In samples containing 25.0 or more genome copies/μL, SARS-CoV-2 was detected by 98.3% of the participating laboratories. Laboratories applying commercial tests scored significantly better (

Indexed as

COVID-19SARS-CoV-2HumansLaboratoriesRNA, ViralSensitivity and SpecificityRNA, ViralCOVID-19Europeexternal quality assessmentmolecular diagnosticsSARS-CoV-2variants

Identifiers

PMID36445090
PMCPMC9769866
OpenAlexW4310465784

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.