Evidence map›Paper›PMID 36444994›Full record

ArticleHematology (Amsterdam, Netherlands)2022

Dapsone-induced methemoglobinemia and hemolysis in a woman without G6PD deficiency presenting with idiopathic urticaria.

Yang Hu, Mimansa Geere, Maham Awan, Andrew D Leavitt, Laura E Brown, Hadley J Pearson, Jocelyn S Gandelman, Scott C Kogan

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Hematology (Amsterdam, Netherlands), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yang HuDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA.
Mimansa GeereDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA.
Maham AwanDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA.
Andrew D LeavittDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA.
Laura E BrownDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA.
Hadley J PearsonDepartment of Dermatology, University of California San Francisco, San Francisco, CA, USA.
Jocelyn S GandelmanDepartment of Dermatology, University of California San Francisco, San Francisco, CA, USA.
Scott C KoganDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-2395-8479
University of California, San Francisco · USUniversity of Wisconsin–Madison · US

Funding

Integrated Training For Physician-ScientistsT32GM140935 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher, Jeniel E Nett · 2021 to 2026
$6.5M
NIGMS NIH HHS T32 GM140935
6 · The paper itself

Abstract

backgroundThe appearance of bite cells associated with methemoglobinemia can be caused by oxidizing drugs such as dapsone in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency or high drug serum levels. Bite cells are often pathognomonic for oxidant injury in patients with G6PD deficiency and suggest active hemolysis. CASE PRESENTATION: We report a case of a woman with no prior history of G6PD deficiency who presented with anemia, methemoglobinemia and bite cells on peripheral blood smear after dapsone therapy for new onset idiopathic urticaria. Laboratory tests for G6PD, blood count and liver function were within normal limits prior to initiation of therapy. During the patient's hospital course, moderate methemoglobinemia and anemia were identified despite mildly increased serum G6PD level. These pathologies were reversed upon stopping dapsone therapy.

conclusionThis case highlights the potential for therapeutic levels of dapsone to induce side effects in patients without G6PD deficiency and highlights the importance of routine blood monitoring for anemia and hemolysis during the course of drug therapy.

Indexed as

Glucosephosphate Dehydrogenase DeficiencyMethemoglobinemiaUrticariaDapsoneFemaleHemolysisHumansDapsoneanemiabite cellsdapsonedermatologyG6PDGlucose-6-phosphate dehydrogenaseheinz bodiesmethemoglobinemia

Identifiers

PMID36444994
PMCPMC9788447
OpenAlexW4310258552

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.