Evidence map›Paper›PMID 36444981›Full record

ArticleTherapeutic advances in respiratory disease

Combination of anti-glycopeptidolipid-core IgA antibody and clinical features for diagnosing potential nontuberculous mycobacterium pulmonary disease in routine practice.

Takuya Iwasaki, Fumihiro Yamaguchi, Makoto Hayashi, Hitoshi Kobayashi, Kento Hirata, Kenta Miyo, Chika Kondo, Mamiko Kanzaki, Kazusawa Tei, Takashi Abe and 6 more

Open access · goldAbstract read
In one paragraph

Article in Therapeutic advances in respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Takuya IwasakiDepartment of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
Fumihiro YamaguchiDepartment of Respiratory Medicine, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama 227-8501, Japan.ORCID 0000-0003-1611-6991
Makoto HayashiDepartment of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
Hitoshi KobayashiDepartment of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
Kento HirataDepartment of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
Kenta MiyoDepartment of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
Chika KondoDepartment of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
Mamiko KanzakiDepartment of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
Kazusawa TeiDepartment of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
Takashi AbeDepartment of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
Shunsuke SakakuraDepartment of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
Daisuke InoueDepartment of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
Yohei YamazakiDepartment of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
Hidetsugu TatenoDepartment of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
Takuya YokoeDepartment of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
Yusuke ShikamaDepartment of Respiratory Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
Showa University Fujigaoka Hospital · JPShowa University Northern Yokohama Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe anti-

objectivesThe study aim was to assess the efficacy of the combination of anti-MAC antibodies and clinical findings for diagnosing potential NTM-PD.

methodsThis cross-sectional study included 938 patients tested using the anti-MAC antibody. NTM-PD was diagnosed by multiple positive cultures of the same species in sputum samples. Multivariate logistic regression models were used to identify the clinical factors related to NTM-PD.

resultsOverall, 19.6% (184/938) of participants were diagnosed with NTM-PD. In multivariate analysis, positive anti-MAC antibodies, low body mass index, absence of malignancy, and cavity-forming lung lesions were significantly associated with NTM-PD at diagnosis. The positive rates of the anti-MAC antibody test were 79.4% (135/170) for MAC and 55.6% (5/9) for

conclusionsBronchoscopic examinations should be performed especially in certain types of individuals from whom sputum samples cannot be obtained. Anti-MAC antibodies are also positive in patients other than those harboring MAC, but the rate may be low because of the different components in GPLs.

Indexed as

Lung DiseasesTuberculosis, PleuralCross-Sectional StudiesHumansImmunoglobulin ANontuberculous MycobacteriaImmunoglobulin Aanti-glycopeptidolipid-core IgA antibodyMycobacterium abscessus complexMycobacterium avium complexMycobacterium gordonaenontuberculous mycobacterium pulmonary disease

Identifiers

PMID36444981
PMCPMC9716443
OpenAlexW4311580672

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.