Evidence map›Paper›PMID 36444938›Full record

ArticleHistology and histopathology2023

LncRNA CERS6-AS1, sponging miR-6838-5p, promotes proliferation and invasion in cervical carcinoma cells by upregulating FOXP2.

Kun Yan, Chunyan Hu, Chen Liu, Guanghua Chu, Xinru Wang, Shuyun Ma, Long Li

Abstract read
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In one paragraph

Article in Histology and histopathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kun YanThe Second Department of Gynecology, Northwest Women and Children Hospital, Xi'an, China.
Chunyan HuThe Second Department of Gynecology, Northwest Women and Children Hospital, Xi'an, China.
Chen LiuThe Second Department of Gynecology, Northwest Women and Children Hospital, Xi'an, China.
Guanghua ChuThe Second Department of Gynecology, Northwest Women and Children Hospital, Xi'an, China.
Xinru WangThe Second Department of Gynecology, Northwest Women and Children Hospital, Xi'an, China.
Shuyun MaDepartment of Gynecology and Obstetrics, The First Affiliated Hospital, Xi'an Medical University, Xi'an, China.
Long LiDepartment of Gynecology and Obstetrics, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China. longli_obs@126.com.
Northwest Women's and Children's Hospital · CNFirst Affiliated Hospital of Xi'an Jiaotong University · CNXi'an Medical University · CN

Funding

General Project of Science and Technology Department of Shaanxi Province 2019SF-024Shaanxi Administration of Traditional Chinese Medicine in China 15-LC044
6 · The paper itself

Abstract

Cervical cancer (CC) is a common disease in women characterized by high recurrence rate. LncRNA ceramide synthase 6 antisense RNA 1 (CERS6-AS1) has been found to play a crucial role in the progression of breast cancer and pancreatic cancer. Nevertheless, the regulatory role of CERS6-AS1 in CC remains largely unclear. Here, we found that the expression of CERS6-AS1 was upregulated in CC tissues and cell lines compared with adjacent tissues and normal human cervical epithelial cells. CERS6-AS1 overexpression promoted proliferation and invasion, and inhibited apoptosis in CC cells, while silencing of CERS6-AS1 led to the opposite results. CERS6-AS1 was verified as a sponge of miR-6838-5p by RNA pull-down and luciferase reporter gene assays. Functional investigations revealed that CERS6-AS1 knockdown inhibited proliferation and invasion, and promoted apoptosis in CC cells, which was reversed by miR-6838-5p inhibitor. Furthermore, forkhead box P2 (FOXP2) was identified as a target for miR-6838-5p, and overexpression of miR-6838-5p decreased the expression level of FOXP2. Besides, CERS6-AS1 was able to sponge miR-6838-5p to accelerate CC cell proliferation and invasion and inhibited cell apoptosis through upregulating FOXP2 expression. In general, CERS6-AS1 was able to regulate CC cell proliferation, invasion and apoptosis by the miR-6838-5p/FOXP2 axis, which suggested that CERS6-AS1 may be a potential target for the treatment of CC.

Indexed as

MicroRNAsRNA, Long NoncodingUterine Cervical NeoplasmsCell Line, TumorCell MovementCell ProliferationFemaleForkhead Transcription FactorsGene Expression Regulation, NeoplasticHumansMembrane ProteinsRNA, AntisenseSphingosine N-AcyltransferaseCERS6 protein, humanForkhead Transcription FactorsFOXP2 protein, humanMembrane ProteinsMicroRNAsRNA, AntisenseRNA, Long NoncodingSphingosine N-Acyltransferase

Identifiers

PMID36444938
OpenAlexW4310462239

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.