ArticleAnnals of Saudi medicine
The pattern of chromosomal abnormalities in recurrent miscarriages: a single center retrospective study.
Article in Annals of Saudi medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- Recurrent pregnancy loss: systematic review and meta-analysis of overall prevalence and the distribution of major etiological categories.Frontiers in medicine · 2026Pooled it
- Chromosomal Abnormalities in Couples Experiencing Recurrent Implantation Failure in West of Iran: A Case-Control Study.Molecular genetics & genomic medicine · 2025Article
- Homozygosity for Robertsonian Translocation (14q;15q) in a Newborn with a Familial History of Recurrent Abortion and Newborns Affected by Hepatosplenomegaly: A Case Report.Journal of reproduction & infertilityArticle
- Chromosomal abnormalities in couples with recurrent pregnancy loss: a 16-year cross-sectional study of 4030 cases from Turkey.Annals of Saudi medicineArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
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Abstract
backgroundChromosomal abnormalities are more common in first trimester recurrent miscarriages (RM). Chromosomal anomalies affect approximately 2%-8% of couples with RM.
objectivesEvaluate the spectrum and the frequencies of chromosomal anomalies in RM.
designA retrospective hospital record-based descriptive study.
settingA tertiary care center in Turkey. PATIENTS AND
methodsWe studied couples with RM between October 2020 and January 2022. Relevant family and medical history, clinical examination and the results of karyotype were statistically analyzed.
main outcome measuresPrevalence and types of chromosomal aberrations in couples with RM. SAMPLE SİZE: 362 couples with a history of RM
resultsAmong the 362 couples, 14 cases (3.86%) had chromosome abnormalities. Eight cases (57.14%) were structural anomalies and six cases (42.86%) were numerical chromosomal aberrations. We found five balanced translocations (67.5%) and three Robertsonian translocations (37.5%). The prevalence of polymorphic variants was 51/362 (14.1%).
conclusionsThis study supports the conclusion that clinicians should understand the importance of chromosome analysis in these couples and direct them to karyotyping after two abortions in order to exclude the possibility of a genetic cause of RM. LIMITATIONS: Single-center study and retrospective. CONFLICT OF INTEREST: None.
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