ArticleImmunity, inflammation and disease2022
Diet-induced obesity results in impaired oral tolerance induction.
Article in Immunity, inflammation and disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 2 citations in OpenAlex.
- High Fat and Sugar Diet Increases Enteric cDC1 and Oral Antigen-Specific Tregs.Journal of immunology research · 2025Article
- Diet-induced obesity results in impaired oral tolerance induction.Immunity, inflammation and disease · 2022Article
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5 authors at 1 institution in 1 country.
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Abstract
introductionObesity increases the risk of several diseases, such as type 2 diabetes mellitus and cardiovascular disease. Obesity also affects the immune system. When dietary lipids are transported via the lymphatics, they pass the mesenteric lymph nodes (mLNs). In these secondary lymphoid organs, immune responses towards pathogens are generated, or tolerance against harmless antigens is induced.
methodsIn this study, the effects of diet-induced obesity (DIO) on mLN induced oral tolerance induction were examined in C57BL/6NCrl mice. Therefore, mice were fed a high-fat or a low-fat diet for 14 weeks. After 10 weeks of feeding oral tolerance induction started, ending up in measuring the delayed-type hypersensitivity reaction, the cell subset composition and cytokine expression.
resultsWe detected an impaired oral tolerance induction during DIO, but changes were reversible after switching the feed to standard chow. Thus, the altered immunological function of mLNs depends on the intake of dietary lipids. Additionally, our results show an influence of the microenvironment on the development of oral tolerance during DIO as oral tolerance was induced in transplanted peripheral lymph nodes.
conclusionThis indicates a functional influence of dietary lipids on stromal cells involved in immune system induction in the mLNs.
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