Evidence map›Paper›PMID 36444349›Full record

ArticleCellular and molecular bioengineering2022

Encapsulation of Manganese Porphyrin in Chondroitin Sulfate-A Microparticles for Long Term Reactive Oxygen Species Scavenging.

Fei San Lee, Kayla E Ney, Alexandria N Richardson, Rebecca E Oberley-Deegan, Rebecca A Wachs

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular bioengineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Fei San LeeDepartment of Biological Systems Engineering, University of Nebraska-Lincoln, 4240 Fair St, Lincoln, NE 68583-0900 USA.
Kayla E NeyDepartment of Biological Systems Engineering, University of Nebraska-Lincoln, 4240 Fair St, Lincoln, NE 68583-0900 USA.
Alexandria N RichardsonDepartment of Biological Systems Engineering, University of Nebraska-Lincoln, 4240 Fair St, Lincoln, NE 68583-0900 USA.
Rebecca E Oberley-DeeganDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198 USA.
Rebecca A WachsDepartment of Biological Systems Engineering, University of Nebraska-Lincoln, 4240 Fair St, Lincoln, NE 68583-0900 USA.ORCID 0000-0001-5735-6284
University of Nebraska–Lincoln · USNebraska Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Oxidative stress due to excess reactive oxygen species (ROS) is related to many chronic illnesses including degenerative disc disease and osteoarthritis. MnTnBuOE-2-PyP Methods: Methacrylated chondroitin sulfate-A MPs (vehicle) and BuOE MPs were synthesized Results: BuOE MPs were successfully encapsulated in MACS-A MPs and exhibited a slow-release profile over 84 days. BuOE maintained high potency in superoxide scavenging after encapsulation and after 84 days of incubation at 37 °C as compared to naked BuOE. Vehicle and BuOE MPs (100 Conclusions: BuOE MPs can be successfully fabricated and maintain potent superoxide scavenging capabilities up to 84-days. Supplementary Information: The online version contains supplementary material available at 10.1007/s12195-022-00744-w.

Indexed as

AntioxidantDegenerative disc diseaseDrug deliveryOxidative stressSOD mimic

Identifiers

PMID36444349
PMCPMC9700555
OpenAlexW4306249543

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.