Evidence map›Paper›PMID 36444304›Full record

ArticleiScience2022

Chromodomain helicase DNA-binding domain 2 maintains spermatogonial self-renewal by promoting chromatin accessibility and mRNA stability.

Ziqian Min, Huan Xin, Xiaowen Liu, Jingyu Wan, Ziling Fan, Xinxu Rao, Jiahui Fan, Lifang Yang, Dan Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. In vitro models of the male reproductive system: applications for developmental and reproductive toxicology.Toxicological sciences : an official journal of the Society of Toxicology · 2025
    Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ziqian MinDepartment of Life Science, College of Biology, Hunan University, 410012 Changsha, China.
Huan XinDepartment of Life Science, College of Biology, Hunan University, 410012 Changsha, China.
Xiaowen LiuDepartment of Life Science, College of Biology, Hunan University, 410012 Changsha, China.
Jingyu WanDepartment of Life Science, College of Biology, Hunan University, 410012 Changsha, China.
Ziling FanDepartment of Life Science, College of Biology, Hunan University, 410012 Changsha, China.
Xinxu RaoDepartment of Life Science, College of Biology, Hunan University, 410012 Changsha, China.
Jiahui FanDepartment of Life Science, College of Biology, Hunan University, 410012 Changsha, China.
Lifang YangCancer Research Institute, Xiangya School of Medicine, Central South University, 410078 Changsha, China.
Dan LiDepartment of Life Science, College of Biology, Hunan University, 410012 Changsha, China.
Hunan University · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chromodomain helicase DNA-binding domain 2 (CHD2) is a chromatin remodeling factor involved in many developmental processes. However, its role in male germ cell development has not been elucidated. Here, we confirm that CHD2 expression is enriched in the male germline. In a heterozygous knockout mouse model of

Indexed as

alternate contactBiological sciencescell biologymolecular mechanism of gene regulationtranscriptomics

Identifiers

PMID36444304
PMCPMC9700024
OpenAlexW4308661069

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.